依达拉奉联合羟乙基淀粉治疗急性脑分水岭梗死临床疗效观察  

Clinical Efficacy of Edaravone Combined with Hydroxyethyl Starch in Treatment of Acute Cerebral Watershed Infarction

作　　者：郑立宏[1] 张爱民[1] 欧阳取平[1] 

机构地区：[1]北京市顺义区医院神经内科,北京101300

出　　处：《中国医药导刊》2011年第8期1358-1359,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:观察依达拉奉联合羟乙基淀粉治疗脑分水岭梗死临床疗效。方法:将86例急性脑分水岭梗死的患者随机分为治疗组44例和对照组42例,对照组常规活血,抗血小板聚集药物同时予羟乙基淀粉500ml静点治疗,治疗组在对照组基础上加用依达拉奉治疗,治疗前及治疗10天行神经功能缺损程度评分并判断疗效。结果:治疗10天后两组患者神经功能缺损评分较治疗前均有好转(P<0.01),治疗组神经功能缺损评分明显低于对照组(p<0.01);治疗组患者神经功能缺损评分减少值明显高于对照组(P<0.01)。两组患者均未出现明显不良反应。结论:依达拉奉联合羟乙基淀粉治疗急性脑分水岭梗死临床疗效安全有效。Objective：To assess the effects of edarasone combined with hydroxyethyl starch on acute cerebral watershed infarction.Methods： 86 patents with acutc cerebral watershed infaretion were nmdomly divided into trcatment group of 44 patients and the control group, 42 palients in the conlrol group of normal blood enculation,anti-platelet aggregation drugs while 1 500ml intravenous hydroxyethyl starch treatment,the trcatment group were based on the use of edatavone treatment,before treatment and 10 days of nerve function dcficit score and to determine efficacy.Results：10 days after the tow groups of patients with neurological deficit scores were better tha before treatment（P〈0.01）,treatment group.neurological deficit score was significantly lower than the control group （P〈0.01）;patients treated with reduced ncurological deficit scores valac was signigicantly higher （P〈0.01）.Two groups of patients were no obvious adverse reactions.Conclusion：The combined hydroxycthyl starch edarvone treatment of acute cerebral watershed infarction safe and effective clinical trcatmetn.

关 键 词：依达拉奉 羟乙基淀粉 急性脑分水岭梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R971[医药卫生—临床医学]