喹硫平与传统抗精神病药治疗精神分裂症临床效果比较研究  

The Comparative Study of the Clinical Effectiveness Between Quetiapine and Conventional Antipsychotics on Schizophrenia

作　　者：李英[1] 叶莉英[1] 童梓顺[1] 

机构地区：[1]广州市精神病医院精神科,广州510170

出　　处：《中国医药导刊》2011年第9期1535-1536,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:比较研究喹碗平与传统抗精神病药治疗精神分裂症临床效果。方法:选择2007年5月～2010年1月在我科住院的精神分裂症患者96例作为研究对象。随机将其分为观察组和对照组各48例。对照组予以氯丙嗪口服,起始量为100mg/d,根据临床疗效和不良反应调整剂量,最高剂量可达1000 mg/d.;观察组予以喹硫平(英国Zencea公司生产),起始量为200mg/d,视临床疗效和不良反应调整剂量,最高剂量可达700 mg/d.。疗程均为8周。结果:两组治疗前后PANSS评分阳性症状、阴性症状、精神病理及总分比较均明显改善,差异均有统计学意义(P<0.01);治疗后,观察组PANSS评分阳性症状、阴性症状及总分与对照组比较,差异均有统计学意义(P<0.05),精神病理评分下降与对照组比较差异无统计学意义(P>0.05);观察组的总有效率为85.42%,对照组总有效率为66.67%,两组总有效率比较,经x^2检验,x^2=4.631,P>0.05,差异有统计学意义。说明观察组疗效优于对照组。结论:喹硫平替换传统抗精神病药治疗精神分裂症效果明显,有效率优于传统抗精神病药,值得推广使用。Objective：To compare the clinical effectiveness between quetiapinc and the conventional antipsychotics on schizophrenia. Methods： 96 patients with schizophrenia from May 2007 to January, 2010 were selected as subjects and randomly allocated into two group including observation group and control group, each of which had 48 cases. In control group, the patients received chloropromazine Orally with the dose of 100mg/d, It was allowable to adjust the dosage according to the clinical effectiveness and side effect and the maximum dosage could be 1000mg/d. In observation group, the patients received qnetiapine （Zencea Company, Britain） with the initial dosage of 200mg/d, which could be adjusted according to the clinical effectiveness and side effect and the maximum dosage cannot be larger than 700mg/d. The course of treatment was 8 weeks. Results： Compared with pre-treatment, PANSS score including positive symptoms, negative symptoms, psychopathology and total score clearly improved aider treatment and there was statistical significance between two kinds of circumstance. For PANSS score such as positive symptoms, negative symptoms and total score, there was significant difference between observation group and control group （P〈0.05）. There was no significant diffcrence between two groups in the reduction of psychopathology （P〉0.05）. The total effective rates were 85.42% in observation group and 66.67% in control group respectively, x 2 test demonstrated that the total effective rate in two groups presented statistical significance （x ±4.631, P〈0.05）, suggesting that observation group surpassed the control group. Conclusions： Compared with eonvenlional antipsychotics, quetiapine can evidently improve schizophrenia with higher effective power and was worthy to be generalized.

关 键 词：精神分裂症 喹硫平 氯丙嗪 阳性与阴性症状量表 

分 类 号：R749.3[医药卫生—神经病学与精神病学]