栓塞型载卡培他滨微胶囊的性能  

Properties of embolic microcapsules loading capecitabine

作　　者：孙学战[1] 刘源岗[1,2] 王士斌[1,2] 陈爱政[1,2] 骆志勇[1] 

机构地区：[1]华侨大学化工学院,厦门361021 [2]华侨大学制药工程研究所,厦门361021

出　　处：《复合材料学报》2011年第5期106-111,共6页Acta Materiae Compositae Sinica

基　　金：国家863计划(2006AA02A118);国家自然科学基金(31000441);福建省自然科学基金(2009J01253)

摘　　要：以生物相容性好且可生物降解的海藻酸钠(Sodium Alginate,Alg)、几丁聚糖(Chitosan,Chi)为壁材,采用静电液滴装置制备了球形度好、表面光洁、分散性好、平均粒径为210μm的海藻酸钙(Calcium Alginate,Ca-Alg)胶珠,并以卡培他滨(CAP)为模型药物,采用一步法和两步法制备了栓塞型载CAP Ca-Alg/Chi微胶囊,并考察了CAP浓度对微胶囊载药量和药物释放的影响。结果表明:随着CAP浓度的增大,载药量增大,包封率却随之减小;微胶囊在0.5 h内的累积释放量不到20%,无突释效应;微胶囊有一定的缓释性能,有望成为一种栓塞型抗肿瘤药物新剂型。The Ca-Alg（Sodium Alginate） beads with smooth surface,good sphericity and dispersivity,and average size of 210 μm were prepared by the electronic droplet generator,and Alg and chitosan（Chi） were used as wall materials.Then embolic Ca-Alg/Chi microcapsules loading CAP（Capecitabine） were prepared by one-step method and two-step method.Effect of CAP concentrations on drug-loading and drug-release of the microcapsules were investigated.The results show that the drug-loading increases with the CAP concentrations,but the encapsulation efficiency decreases.The cumulative amount of CAP released from the microcapsules is lower than 20% in 0.5 h,which indicate that there is no initial burst release.The embolic microcapsules are likely to be a new dosage form of embolic anti-tumor drugs.

关 键 词：海藻酸钠 几丁聚糖 微胶囊 卡培他滨 缓释 

分 类 号：R318.08[医药卫生—生物医学工程] TB34[医药卫生—基础医学]