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作 者:李斌[1] 余耀[2] 贺轶锋[2] 樊嘉[2] 吴志全[3] 周俭[3] 钦伦秀[3] 叶青海[3] 孙惠川[3] 邱双健[3]
机构地区:[1]复旦大学附属中山医院超声诊断科,上海200032 [2]复旦大学附属中山医院肝外科,上海200032 [3]复旦大学肝癌研究所
出 处:《中华肝胆外科杂志》2011年第10期805-808,共4页Chinese Journal of Hepatobiliary Surgery
摘 要:目的研究原发性肝癌患者肝切除术后肝功能代偿不全的危险因素。方法对2007年7月1日至12月31日在复旦大学附属中山医院肝外科行手术切除的562例Child—PughA级肝细胞肝癌患者资料进行回顾性分析,探讨术后肝功能代偿不全及肝功能衰竭病死的危险因素。结果术前高总胆红素(total bilirubin,TB)、低前白蛋白(prealbumin,PA)是术后肝功能代偿不全的独立危险因素。ROC曲线显示术前PA预测术后肝功能代偿不全的界值为0.14g/L(灵敏度41.4%,特异度83.1%)。当TB≥20.4umol/L且PA〈0.14g/L时,肝功能代偿不全的发生率为16.0%(OR=7.276,P=0.002)。结论Child—PughA级原发性肝癌肝切除者,术前TB〈20.4umol/L并且PA≥0.14g/L时,术后肝功能恢复较好。Objective To study the risk factors of post-hepatectomy hepatic decompensation (PHD) in patients with hepatocellular carcinoma. Method We reviewed 562 patients with Child-Pugh A classification, who underwent partial hepatectomy for hepatocellular carcinoma at Zhongshan Hospi tal, Fudan University between July 1st 2007 to December 31st 2007, to study the risk factors of hepatic decompensation. Results Preoperative high total bilirubin (TB) and low prealbumin (PA) were independent risk factors of PHD by logistic multivariate analysis ROC analysis revealed the cut-offs of preoperative PA predicting PHD were 0. 14 g/L (sensitivity 41.4%; specificity 83. 1%). The incidence of PHD was 16.0% when TB≥20.4 umol/L and PA〈0. 14 g/L(OR=7. 276, P=0. 002). Conclusion The Child-Pugh A patients recovered well when the preoperative liver function was as fol- lows: TB〈20.4 gmol/L and PA≥0.14 g/L.
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