慢加急性肝衰竭病因及其病理生理机制研究进展  

Research on etiology and pathophysiology of acute-on-chronic liver failure

作　　者：顾广祥[1] 施晓雷[2] 丁义涛[1,2] 

机构地区：[1]南京医科大学鼓楼临床医学院肝胆外科,210008 [2]南京大学医学院附属鼓楼医院肝胆外科

出　　处：《中华肝胆外科杂志》2011年第10期861-864,共4页Chinese Journal of Hepatobiliary Surgery

摘　　要：慢加急性肝衰竭（acute-on-chronic liver failure，ACLF）是国内最常见的肝衰竭类型，其临床表现复杂，病死率极高。ACLF的病理生理学改变目前尚不明确，深入了解ACLF的病理生理学改变有助于临床治疗工作的改善。近年来ACLF的病理生理学研究取得了一定的成就。本文就ACLF的概念、病因及其病理生理学改变作一综述。Acute-on-chronic liver failure is a common form of liver failure characterized by complicated clinical manifestations and high mortality. The pathophysiology of ACLF is still unclear. More efficacious treatments are based mainly on a better understanding of the pathophysiology of ACLF. The advances in the pathophysiology of ACLF have been extremely encouraging in the last few years. In this article, we reviewed the progress of ACLF, its definition, etiology and, pathophysiology.

关 键 词：慢加急性肝衰竭 病因 病理生理学 进展 

分 类 号：R575.3[医药卫生—消化系统]