14-3-3σ蛋白与宫颈癌的关系  

Relationship between 14-3-3σ protein and cervical carcinoma

作　　者：侯艳芳[1] 晁玮霞[1] 齐义军[1,2] 王攀[1] 卜旺雨[1] 牛保华[1,2,3] 

机构地区：[1]河南大学医学院细胞与分子免疫学实验室,开封475004 [2]河南大学医学院病理学教研室,开封475004 [3]河南大学医学院环境医学研究所,开封475004

出　　处：《解剖学杂志》2011年第5期623-625,共3页Chinese Journal of Anatomy

基　　金：国家自然科学基金（30700366,81072039）;河南省教育厅自然科学基金（20118310001）

摘　　要：目的：探讨14-3-3σ蛋白与宫颈癌临床病理特征之间的关系。方法：应用免疫组织化学方法检测14-3-3σ蛋白在正常宫颈粘膜组织、宫颈黏膜上皮内瘤变及宫颈癌中的表达。结果：14-3-3σ蛋白在正常宫颈黏膜组织、宫颈黏膜上皮内瘤变与宫颈癌中的阳性表达率分别为100%（10/10）, 70%（42/60）和43.10%（25/58），在宫颈癌变过程中，14-3-3σ蛋白的表达率逐渐下降。14-3-3σ在高分化癌中的表达高于在中、低分化癌中的表达；14-3-3σ蛋白的表达与肿瘤的病理类型、患者的年龄因素无相关性。结论：14-3-3σ蛋白表达可能与宫颈癌发生、发展及组织分化程度相关，可能成为宫颈癌早期诊断的分子指标，同时也可能成为宫颈癌生物预防和疗效评价的新靶点。Objective= To investigate the expression and significance of 14-3-3σ protein in cervical intraepithelial neoplasia and carcinoma of the cervix. Methods：14-3-3σ were detected by immunohistochemical method in 10 cases of normal cervical mucosa tissues, 60 cases of cervical intraepithelial neoplasia （CIN） and 58 cases of cervical carcinoma （CC）. Results： The positire rates of 14-3-3σ in normal cervical mucosa tissues, cervical intraepithelial neoplasia and cervical carcinoma were 100% （10/10）,70%（42/60） and 43. 10% （25/58） respectively, which were down-regulated stepwise during the development of cervical carcinoma from normal cervical mucosa tissues （P〈0. 05）. The increased expression of 14-3-3σ was observed in high differentiation degree of cervical carcinoma compared to moderate and poor differentiation degree （P〈O. 05）. There were no significant differences in the histology type and age （P〉O. 05）. Conclusion： 14-3-3~ protein may be correlated to the occurrence, development and differentiation status of cervical carcinoma, and may have the potential to become biomarkers for early diagnosis of cervical carcinoma and target molecules of cervical carcinoma prevention,

关 键 词：14-3-3σ蛋白 上皮内瘤变 宫颈癌 免疫组织化学 

分 类 号：R730.231[医药卫生—肿瘤]