基于近红外光谱的脑立体定向手术导航技术研究  

Research on Navigation Technology in Stereotactic Bain Surgery Based on Near Infrared Spectroscopy

作　　者：陶玲[1] 钱志余[1] 朱晓芬[1] 

机构地区：[1]南京航空航天大学自动化学院,南京210016

出　　处：《中国生物医学工程学报》2011年第5期738-744,共7页Chinese Journal of Biomedical Engineering

基　　金：国家高技术研究发展计划(863计划)(2007AA02Z4A9);国家自然科学基金(61075107)

摘　　要：针对目前脑立体定向手术过程中无法解决的穿刺路径偏移问题,提出一种基于近红外光谱技术的神经外科手术实时导航和穿刺路径实时纠错的新方法。通过回归分析建立近红外参数信息和影像信息之间的数学关联模型,通过生物组织光学参数引导手术导航过程;将影像计划穿刺路径锥形化,获得可能偏移路径的灰度信息作为近红外路径偏移纠正的先验知识,采用曲率匹配的算法对偏移路径进行拟合,实现基于近红外光谱技术的术中移位纠错。实验结果表明,提出的方法可以达到近红外实时导航和实时纠偏的目的,并可以实现误差范围内的有效定位,误差范围不超过1 mm。At present,navigation path deviation is one unsolvable problem in stereotactic brain surgery.In this paper,a new method for neurosurgical real-time navigation and navigation path real-time correction based on near infrared spectroscopy（NIRS） was presented.The mathematical model between near infrared reduced scattering coefficient and the image data was established by regression analysis,and surgical navigation was guided by optical properties of biological tissue.The planned navigation path from image information was coned,and the gray information of deviation path from cone regarded as the priori knowledge of path correction based on NIRS.Intra-operative path correction was realized by the deviation path fitting based on curvature matching algorithm.Experimental results showed that the presented algorithm can meet the requirement of real-time navigation and path correction,and can attain an effective localization with a small error less than 1 mm.

关 键 词：近红外光谱 数学模型 实时导航 路径纠错 脑立体定向手术 

分 类 号：R318.6[医药卫生—生物医学工程]