不同时间窗及疗程的高压氧治疗对急性脑梗死的影响  

The effect of different time-window and courses of hyperbaric oxygenation therapy in patients with acute ischemic stroke

作　　者：王晓红[1] 黄礼群[1] 龚琴[1] 李宁[2] 

机构地区：[1]广州军区武汉总医院康复理疗科,武汉430070 [2]第三军医大学新桥医院高压氧治疗中心,重庆400037

出　　处：《重庆医学》2011年第31期3140-3142,共3页Chongqing medicine

摘　　要：目的探讨不同时间窗及疗程的高压氧治疗对急性脑梗死疗效的影响。方法 140例急性脑梗死患者按从发病到高压氧治疗的时间窗及疗程分为7组,对各组患者在高压氧治疗前、后分别进行神经功能缺损程度、日常生活活动能力(ADL)评分及脑电图检查,并进行各组之间的比较。结果在进行同样疗程的高压氧治疗中,越早进行高压氧治疗,患者美国国立卫生研究院卒中量表(NIHSS)、ADL评分及脑电图结果越好,差异有统计学意义(P<0.05);相同时间开始高压氧治疗,疗程越长,患者的NIHSS、ADL评分及脑电图结果越好,差异有统计学意义(P<0.05)。结论高压氧治疗急性脑梗死疗效可靠,在脑梗死后12h以内开始高压氧治疗效果最好,7d后开始行高压氧治疗仍有临床疗效,并且疗程越长疗效越佳。Objective To evaluate the efficacy and safety of different time-windows and courses of hyperbaric oxygenation in patients with acute ischemic stroke.Methods 140 patients were divided into 7 groups according to the starting time-windows and courses of hyperbaric oxygenation.hyperbaric oxygenation were administered at less than 12 h,12 h to 7 d,more than 7 days after infarction with courses of 20 or 40 d.National institues of health stroke scale（NIHSS）,activity of daily life（ADL） and electroencephalogram（EEG） were examined pre-and post-treatment.Results With the same course of hyperbaric oxygenation,the earlier hyperbaric oxygenation,the better the NIHSS,ADL and EEG evaluation got（P0.05）;With the same time-window of hyperbaric oxygenation,the longer the course of hyperbaric oxygenation,the better the NIHSS,ADL and EEG evaluation got（P0.05）.Conclusion The efficacy and safety of hyperbaric oxygenation are reliable in acute ischemic stroke,and the best therapeutic time-window is less than 12 h after stroke attacked.But there still exist significant improvement in 7 d post-stroke,and the longer the course took,the better the result improved.

关 键 词：高压氧 脑梗死 神经功能 日常生活活动能力 脑电图 

分 类 号：R743.3[医药卫生—神经病学与精神病学]