活化转录因子4与肿瘤的发生发展及耐药  

Activating transcription factor 4 in malignant tumors and drug resistance

作　　者：张竹红[1] 付志燕[1] 刘成虎[1] 

机构地区：[1]南开大学医学院肿瘤免疫系,天津300071

出　　处：《国际肿瘤学杂志》2011年第10期735-737,共3页Journal of International Oncology

基　　金：天津市科技计划基金资助项目（08ZCGYSH04700）

摘　　要：ATF4是活化转录因子即循环AMP反应元件结合蛋白家族成员之一。ATF4在肿瘤中受肿瘤微环境因素的诱导呈高表达，并进一步影响肿瘤的生长、凋亡、浸润、转移及耐药。因此，ATF4可能作为肿瘤治疗的潜在靶点。Activating transcription factor 4 （ATF4）, one of the activating transcription factors, belongs to the cyclic AMP response element binding protein family. The expression of ATF4 is up-regulated by tumor micro-environmental factors. And ATF4 regulates the processes of tumor growth, infiltration, metastasis, apoptosis and drug resistance. Therefore, ATF4 might serve as a potential therapeutic target in cancer.

关 键 词：转录因子 肿瘤 生长 药物疗法 

分 类 号：R730.2[医药卫生—肿瘤]