快速右心室起搏心力衰竭犬模型的建立  

Animal model of congestive heart failure induced by pacing tachycardia

作　　者：周声安 史扬[2] 李小鹰[2] 吴立荣[3] 米亚非[2] 付治卿[2] 

机构地区：[1]山东省莒县人民医院心血管内科,日照276500 [2]解放军总医院老年心血管一科 [3]贵阳医学院附属医院心血管内科

出　　处：《中华老年心脑血管病杂志》2011年第11期1029-1031,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的应用改进的快速右心室起搏的方法制备慢性心力衰竭犬模型,分析模型相应的临床和血流动力学及病理变化。方法选择比格犬12只,随机分为起搏组(7只)和对照组(5只),起搏组采用230 ppm的频率快速右心室起搏4周,之后改用180 ppm的频率维持右心室起搏4周。对照组正常喂养不处理,4周后测量相应指标。起搏组起搏前、起搏1、8周后,分别行心脏超声、血流动力学检测,之后处死取心脏做病理切片检查。结果与对照组和同组起搏前比较,起搏组犬起搏4、8周后,出现慢性心力衰竭的相应临床表现;超声心动图示各心腔内径均变大,左心室射血分数明显下降,左心导管示左心室舒张末压力增加,左心室收缩末压力及左心室内压最大上升及下降速率降低,差异有统计学意义(P<0.05,P<0.01)。结论经过改进的快速右心室起搏方法,可以产生相对稳定的慢性心力衰竭犬模型。Objectives The purpose of this study was to establish a controllable canine model of chronic congestive heart failure, using rapid right ventricular pacing. Methods Twelve Beagles were divided randomly into 2 groups, namely control group and CHF group. The control group didn＇t receive sham operation,while CHF group received rapid right ventricular pacing at the rate of 230 beats per minute for 4 weeks. In the following 4 weeks,a reduced rate,180 beats per minute,was used. Results Heart failure was induced in all Beagles by rapid ventricular pacing（230 beats/min） for 4 weeks. Doppler echocardiography indicated that chambers heart increased, and ejection fraction was significantly reduced. Left ventricular end diastolic pressure increased, Left ventricular end systolic pressure and±dp/dt decreased in the hemodynamic test （P 〈 0.05, P 〈 0.01）. With the maintenance rate of 180 beats/min for 4 weeks, all parameters above remained stable. Conclusions The modified experimental heart failure is a long-term stable model of chronic congestive heart failure.

关 键 词：心力衰竭 心室功能 右 心脏起搏器 人工 血流动力学 超声心动描记术 每搏输出量 模型 动物 

分 类 号：R-332[医药卫生] R541.6