胆囊癌中骨桥蛋白和MMP-9的表达及其意义  

Expression of Osteopontin (OPN) and MMP-9 in Gallbladder Cancer and Its Clinical Significance

作　　者：许桂祥[1] 王振旭[1] 许准 胡景津[1] 王林[1] 陶可涛[1] 何颂雄[1] 张桂欣[1] 安鑫[3] 薛冰川[3] 

机构地区：[1]青岛阜外心血管病医院普外科,山东青岛266034 [2]青岛外语学校,山东青岛266000 [3]山西医科大学第三医院普外科,山西太原030053

出　　处：《中国现代医生》2011年第31期61-62,70,共3页China Modern Doctor

摘　　要：目的了解胆囊癌组织中骨桥蛋白和MMP-9的表达及其意义。方法选择正常的胆囊组织10例、胆囊腺瘤组织10例和胆囊癌组织40例,运用免疫组织化学方法,检测OPN和MMP-9的表达水平,对OPN和MMP-9表达的相关性进行分析研究。结果胆囊癌组织中OPN和MMP-9的表达水平明显高于胆囊组织和胆囊腺瘤组织(P<0.05),其中在有转移的胆囊癌组织中OPN的表达水平明显高于没有转移的胆囊癌组织(P<0.05)。胆囊癌组织中OPN和MMP-9的表达具有一致性(P<0.05)。结论 OPN与MMP-9的表达情况与胆囊癌浸润、转移发生有密切的关系,本实验结果证实MMP-9和OPN均阳性表达时对胆囊癌转移及预后有重要的预测价值。Objective To explore expression of osteopontin and MMP-9 in gallbladder cancer and its clinical significance. Methods The expression of osteopontin and MMP-9 was detected by immunohistochemical method in 40 cases of gallbladder cancer, 10 cases of normal gallbladder and 10 cases of gallbladder adenoma. The relationship between the expression of osteopontin and MMP-9 was analyzed. Results The positive expression rates of osteopontin and MMP-9 in gallbladder cancer tissues were significantly higher than that in normal gallbladder tissues and gallbladder adenoma tissues （ P 〈 0.05 ）. The positive expression rates of osteopontin in patients of NEVIN IV, V stages were higher than that in patients of NEVIN I , II, m stages ） （P 〈 0.05 ）. The expression of osteopontin was positively correlated with the expression of MMP-9 （P 〈 0.05 ）. Conclusion Both osteopontin and MMP-9 are significantly related to the metastasis of gallbladder cancer, and overexpression of both osteopontin and MMP-9 has a predictive value for metastasis and recurrence.

关 键 词：胆囊癌 肿瘤转移 骨桥蛋白 MMP-9 免疫组化 

分 类 号：R735.8[医药卫生—肿瘤]