奥氮平与齐拉西酮对精神分裂症患者生活质量影响的对照研究  

Comparative study on the effects of olanzapine and ziprasidone on the life quality of patients with schizophrenia

作　　者：王冬梅[1] 

机构地区：[1]天津市安宁医院,300300

出　　处：《临床精神医学杂志》2011年第5期343-344,共2页Journal of Clinical Psychiatry

摘　　要：目的:比较奥氮平与齐拉西酮对精神分裂症患者生活质量的影响。方法:将68例精神分裂症患者随机分为2组,各34例,分别采用奥氮平和齐拉西酮治疗8周,分别于治疗前及治疗2、4、6、8周采用阳性和阴性症状量表(PANSS)评定疗效,用治疗中出现的症状量表(TESS)评定不良反应,用生活质量综合评定问卷(GQOLI-74)于治疗前和治疗8周评定生活质量。结果:两组间PANSS总分相比差异无显著性(P>0.05)。生活质量综合评定问卷评分两组除物质生活维度无显著变化外,躯体健康、心理健康、社会功能维度分均较治疗前有显著性提高(P<0.05)。治疗后,两组间评分比较差异无统计学意义。结论:奥氮平和齐拉西酮均能提高精神分裂症患者的生活质量。Objective：To investigate influence of Olanzapine and Ziprasidone on quality of life in patients with schizophrenia.Method：A total of 68 patients with schizophrenia were randomly assigned into olanzapine group（n=34） and ziprasidone group（n=34） for the treatment of 8 weeks.The positive and negative symptoms scale（PANSS） was used to evaluated the efficacy,and the treatment emergent symptoms scale（TESS） was used to assess the side effects,generic quality of life inventory（GQOLI-74）were used to evaluate efficacy and quality of life.Results：The two groups showed no significant statistical differences on PANSS and GQOLI-74 score reduction through the treatment.（P〉0.05）.Both of ziprasidone and olanzapine could improve the mental symptoms and life quality of schizophrenics.Conclusion：Both olanzapine and ziprasidone could improve the life quality of patients with schizophrenia.

关 键 词：精神分裂症 奥氮平 齐拉西酮 生活质量 

分 类 号：R749.3[医药卫生—神经病学与精神病学]