拉莫三嗪治疗癫痫的疗效及安全性分析  

ANALYSIS OF EFFICACY AND SAFETY OF LAMOTRIGINE IN EPILEPSY

作　　者：罗榕[1] 刘凌[2] 司洋[2] 方嘉佳[2] 徐鸿儒[2] 赵丽莉[2] 安冬梅[2] 慕洁[2] 

机构地区：[1]四川省峨眉山市人民医院,峨眉山614200 [2]四川大学华西医院神经内科

出　　处：《现代预防医学》2011年第21期4550-4552,4554,共4页Modern Preventive Medicine

摘　　要：[目的]观察拉莫三嗪单药或添加治疗儿童及成人癫痫的临床疗效及安全性。[方法]采用前瞻性自身对照的研究方法,以四川大学华西医院神经内科自2009年5月~2010年5月收治的100例门诊或住院癫痫患者为研究对象,进行12个月以上的拉莫三嗪治疗并进行随访,观察拉莫三嗪对癫痫患者的疗效及安全性。[结果]100例随访观察对象接受拉莫三嗪治疗≥12个月后,达到完全控制的为42例,占42%;治疗有效的34例,占34%;24例患者对拉莫三嗪治疗效果差或无效,占24%,即总应答率为76%。100例患者中难治性癫痫患者34例,26例（76.0%）对拉莫三嗪治疗有应答;拉莫三嗪治疗后脑电图有改善的患者占54%,总体上拉莫三嗪单药或添加治疗各类型癫痫效果肯定,患者年龄、病程、是否为症状性癫痫对其疗效影响不大。100例患者中17例（17%）出现不良反应,其中皮疹最常见。[结论]拉莫三嗪作为一种新型抗癫痫药物,单药治疗或添加治疗成人及儿童各种类型癫痫具有较好的疗效和安全性,尤其对难治性癫痫有一定效果。使用该药需关注患者皮疹等不良事件。[Objective]To analyse the efficacy and safety of lamotrigine（LTG）in epilepsy.[Methods]Used the method of prospective self-control study,since May 2009 to May 2010,100 epilepsy cases of outpatients and inpatients came from Department of Neurology of West China Hospital of Sichuan University were eligible.The LTG treatment lasted for at least 12 months,and the efficacy and side effects were assessed.[Results]One hundred patients received the treatment of LTG at least 12 months,compared with their baseline seizure frequency,42（42.0%）cases＇ disease situation was controlled,34（34.0%）cases were refractory epilepsy,in which 26 patients（76%）were improved after lamotrigine theropy.54% of patients＇ EEG improved after lamotrigine therapy.Generally,LTG was effective to epilepsy.There was no differences in efficacy influenced by epilepsy types,patients＇ age,different courses,idiopathic epilepsy and symptomatic epilepsy.17（17.0%）patients had slight adverse reactions,skin rash was the main adverse reaction.[Conclusion]LTG as a novel anti-epileptic drug has a good efficacy for epilepsy patients,especially for intractable epilepsy.It should pay attention to side effects like rash.

关 键 词：拉莫三嗪 癫痫 疗效 安全性 

分 类 号：R742.1[医药卫生—神经病学与精神病学]