吸氧和早产儿视网膜病变的相关研究  

Study on related factors of retinopathy of prematurity and oxygen

作　　者：郭健[1] 徐国兴[1] 陈金国[2] 

机构地区：[1]福建医科大学附属第一医院眼科,中国福建省福州市350005 [2]福建省妇幼保健院眼科,中国福建省福州市350005

出　　处：《国际眼科杂志》2011年第11期2023-2024,共2页International Eye Science

基　　金：中国福建省自然科学基金资助项目(No.2008J0324);中国福建省科技平台建设资助项目(No.2010Y2003);中国福建省卫生厅青年科研基金资助项目(No.2008-1-34)~~

摘　　要：目的:探讨吸氧时间和吸氧浓度与早产儿视网膜病变(retinopathy of prematurity,ROP)病变分期的关系,以期揭示ROP的关键影响因素和发病机制。方法:选择我院新生儿科住院的出生体质量≤2500g和(或)胎龄≤32wk的早产儿156例作为研究对象。16wk时采用双目间接眼底镜进行眼底检查并记录。结果:确诊为ROP的患儿43例86眼,随着吸氧浓度的升高和时间的延长,ROP的病变程度逐步加重。吸氧浓度≥40%时,35.3%的患儿ROP病变超过3期,吸氧时间≥7d时,27.8%的患儿ROP病变超过3期。结论:规范化的氧疗应当是持续低流量的给氧,即使病情需要高流量给氧,通过缓慢逐步减量的方法也可以有效减少ROP的发生。AIM：To study the relation of oxygen therapy time and concentration and retinopathy of prematurity（ROP） stage.METHODS：The retina of premature infants with birth-weight ≤2500g and gestation-age ≤32 weeks are examined by indirect ophthalmoscope in 16 weeks.RESULTS：There are 43 cases（86 eyes） are diagnosed ROP.The pathological degree is more aggravated with the higher oxygen concentration and longer oxygen therapy time.When the oxygen concentration≥40%,retina pathological degree of 35.3% ROP infants are over III stage.When the time of oxygen therapy ≥7 days,retina pathological degree of 27.8% ROP infants are over III stage.CONCLUSION：The continuing low discharge oxygen therapy is criterion one.When the higher oxygen discharge is needed,the way to cut down oxygen discharge step by step can decrease the incidence of ROP.

关 键 词：氧疗 早产儿视网膜病变 氧浓度 

分 类 号：R774.1[医药卫生—眼科]