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作 者:李媚[1] 刘杏[1] 钟毅敏[1] 曾阳发[1] 孔湘云[1] 曹丹[1] 郭歆星[1]
机构地区:[1]中山大学中山眼科中心眼科学国家重点实验室,广州510060
出 处:《中华眼科杂志》2011年第10期871-875,共5页Chinese Journal of Ophthalmology
基 金:基金项目:广东省科技计划项目(20088030301334);广东省医学科研课题(B2009085)
摘 要:目的观察原发性急性闭角型青光眼(PAACG)周边虹膜切除(SPI)术前后的眼前段相干光断层扫描(AS—OCT)参数改变。方法自身对照研究。连续性收集37例(37只眼)周边虹膜前粘连不超过5个钟点的PAACG发作期患者临床资料,进行回顾性自身对照研究。所有患者均于SPI术前及术后1个月行AS—OCT检查,检查项目包括中央前房深度、前房角开放距离、小梁网与虹膜间面积、前房角隐窝面积、前房宽度、前房容积及晶状体矢高。手术后与手术前检测参数比较,服从正态分布的采用配对t检验,不服从正态分布的采用配对秩和检验。结果37例(37只眼)PAACG患者SPI手术前的AS.OCT检测参数:距巩膜突750μm处,前房角开放距离(0.088±0.078)μm、小梁网与虹膜间面积(0.050±0.048)mm2、前房角隐窝面积(0.059±0.057)mm2、前房面积(12.332±2.457)mm2、前房容积(73.131±16.976)mm2;SPI术后AS—OCT检测参数:距巩膜突750μm处,前房角开放距离(0.125±0.072)μm、小梁网与虹膜间面积(0.091±0.041)Hmm2、前房角隐窝面积(0.095±0.042)mm2、前房面积(14.230±2.000)mm2、前房容积(90.074±16.796)mm2;SPI术后上述检测参数均高于术前,差异有统计学意义(t=-8.015~1.066,P=0.001~0.044)。但中央前房深度、前房宽度及晶状体矢高与术前相比无明显变化,差异无统计学意义(t=-1.505~0.516,P=0.102~0.609)。结论PAACG患者SPI术后可以解除瞳孔阻滞,使前房角开放距离、小梁网与虹膜间面积、前房角隐窝面积增宽,前房面积和容积增加,但前房深度和晶状体矢高不变。Objective To evaluate the changes of anterior segment configuration after surgical peripheral iridectomy (SPI)in patients with primary acute angle closure glaucoma (PAACG) by using anterior segment optical coherence tomography (AS-OCT). Methods This retrospective self control study consisted of thirty-seven eyes of 37 patients with PAACG who were consecutively recruited in Zhongshan Ophthalmic Center. The peripheral anterior synechiae (PAS) of these patients was less than 5 clock time point. Central anterior chamber depth (ACD), angle opening distance (AOD), trabecular iris area (TISA) , angle recess area (ARA), anterior chamber width (ACW) , anterior chamber volume (ACV), and crystalline lens rise (CLR) were measured using AS-OCT before and one month after SPI. Results After SPI, AOD (0. 125 ±0.072) μm, TISA (0.091 ±0.041) mm2, ARA (0.095 ±0.042) mm2, ACA ( 14. 230 ± 2. 000 ) mm2 and ACV ( 90. 074± 16. 796 )mm3 were significantly increased compared with before SPI AOD ( 0. 088 ± 0. 078 ) μm, TISA ( 0. 050 ± 0. 048 ) mm2, ARA ( 0. 059 ±0. 057 ) mm2, ACA ( 12. 332 ± 2. 457 )mm2, ACV (73. 131 ± 16. 976 ) mm3 ( t = - 8. 015 to 1. 066, P = 0. 001 to 0. 044 ), respectively. There were no significantly changes in ACD, ACW and CLR(t = - 1. 505 to 0. 516,P =0. 102 to 0. 609). Conclusions PAACG can be controlled by SP1 resulting in an increase of AOD, TISA, ARA,ACA and ACV, but not ACD or CLR.
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