人脑胶质瘤中proNGF凋亡前信号的研究  

Study on proNGF Apoptosis Pro-signal in Human Brain Gliomas

作　　者：李俊彦[1] 刘俊[1] 孙杰[1] 

机构地区：[1]昆明市第一人民医院神经外科,云南昆明650031

出　　处：《昆明医学院学报》2011年第8期81-84,共4页Journal of Kunming Medical College

摘　　要：目的探讨proNGF(Nerve growth factor precurso)r凋亡前信号在人脑胶质瘤中的表达及其临床意义.方法采用RTPCR(Rever Transcription Poly-merase Chain Reaction)技术检测人脑胶质瘤中proNGF凋亡前信号各因子proNGF、Sortilin及P75的表达,以10例瘤周正常脑组织为对照.结果各因子在胶质瘤中均有表达,正常脑组织中低表达,两组之间比较差异有统计学意义(P<0.05).结论 proNGF凋亡前信号所导致的细胞凋亡参与正常人脑组织及胶质瘤的发生、发展过程,可能是一种正常机体的保护性机制.Objective To observe the expressional changes of proNGF apoptosis pro-signal molecules in human brain gliomas and its clinical meanings.Methods RT-PCR（Reverse transcription poly-merase chain reaction）was used to detect the expressional changes of proNGF,Sortilin and P75 in human brain gliomas,and 10 cases of normal tissue around the gliomas were used as the control.Results All the factors were detected in gliomas,and lowly expressed in normal tissues,and there was statistically significant difference between them（P0.05）.Conclusion The cell apoptosis induced by proNGF plays a very important role in the course of human brain gliomas,and maybe a protection mechanism of human body.

关 键 词：脑 胶质瘤 proNGF 凋亡 

分 类 号：R739.41[医药卫生—肿瘤]