A型肉毒毒素在神经系统疾病中的应用研究进展  

Application progress of botulinum toxin type A in the nervous system diseases

作　　者：江伟[1] 何传斌[1] 

机构地区：[1]解放军电子工程学院医院,安徽合肥230037

出　　处：《中国医药导报》2011年第31期12-14,共3页China Medical Herald

摘　　要：近年来随着A型肉毒毒素作用机制研究的不断深入,其在神经系统疾病中的应用范围日渐扩大。因其肌肉化学性去神经支配效应可用于治疗面肌痉挛、特发性眼睑痉挛、口下颌肌张力障碍、痉挛性斜颈、抽动障碍、脑卒中后肢体痉挛和痉挛性脑瘫;因其植物神经系统效应可用于治疗多涎病症和多汗证;因其镇痛效应可用于治疗各种头痛和神经痛,故A型肉毒毒素已逐渐成为神经科领域一种重要的治疗手段。In recent years, with the deepening study on the mechanism of botulinum toxin type A, the range of its applications in the nervous system diseases continues to expand. Because botulinum toxin type A produces partial chemical denervation of the muscle resulting in a localized reduction in muscle activity, it can be used to treat hemifacial spasm, idio- pathic blepharospasm, oromandibular dystonia, spasmodic torticollis, tic disorder, limb spasticity after stroke and spastic cerebral palsy. In addition, it has recently begun to show some benefit in the control of hyperhidrosis ang excessive salivation disease on account of its effects of the autonomic nervous system. It may also prove useful in treatment of a variety of headache and neuralgia owing to its analgesic effects. Therefore, botulinum toxin type A has become an important treatment option in the field of neurology.

关 键 词：A型肉毒毒素 神经系统疾病 研究进展 

分 类 号：R741[医药卫生—神经病学与精神病学]