甲状腺乳头状癌原发灶与淋巴结转移灶中基质金属蛋白酶-2、组织金属蛋白酶抑制剂-2的表达对比分析  

Comparative analysis of the expression of MMP2 and TIMP2 in primary and lymph node metastatic lesions of papillary thyroid carcinoma

作　　者：陈一峰[1] 张白凌[2] 连云宗[1] 庄建良[3] 

机构地区：[1]福建医科大学附属泉州第一医院病理科,福建泉州362000 [2]福建医科大学口腔系,福建福州350001 [3]福建医科大学附属泉州第一医院肿瘤外科,福建泉州362000

出　　处：《中国医药导报》2011年第31期45-46,49,共3页China Medical Herald

摘　　要：目的:探讨基质金属蛋白酶-2(MMP2),组织金属蛋白酶抑制剂-2(TIMP2)在甲状腺乳头状癌(PTC)中的表达。方法:采用免疫组织化学方法检测86例PTC原发灶及其中40例颈部淋巴结转移性癌灶中MMP2、TIMP2的表达。结果:伴有颈部淋巴结转移的PTC原发灶中MMP2的表达强度高于无淋巴结转移者,而前者TIMP2的表达强度低于后者,差异均有统计学意义(P<0.05);PTC原发灶中MMP2的表达强度高于转移灶,差异有统计学意义(P<0.05),而TIMP2在原发灶与转移灶中表达强度的差异无统计学意义(P>0.05);两者在PTC原发灶和转移灶中表达强度的自身对比差异均有统计学意义(P<0.05)。结论:PTC癌组织中的MMP2/TIMP2表达比例失衡,MMP2起着主导作用,这可能是导致PTC淋巴结转移的因素之一,高MMP2/TIMP2比例蛋白组成的PTC癌细胞亚克隆在转移过程中发挥着重要的作用。Objective： To explore the expressions of matrix metalloproteinase 2（MMP2） and tissue inhibitors of metalloproteinase 2 （TIMP2） in papillary thyroid carcinomas （PTC）. Methods： The expressions of MMP2 and TIMP2 were detected in 86 cases of primary lesions and 40 cases of metastatic foci in cervical lymph nodes by immunohistochemistry. Results： The expression level of MMP2 in primary lesion of PTC with cervical lymph nodes metastases was higher than that without metastases. Otherwise the expression level of TIMP2 of the former was lower than that of the latter. Both differences were statistically significant （P〈0.05）; the expression level of MMP2 in primary lesion of PTC was significantly higher than that of metastatic loci in cervical lymph nodes （P〈0.05）. Whereas the difference between the expression of TIMP2 of the former and that of the latter was not statistically significant （P〉0.05）; the expression levels of MMP2 and TIMP2 between primary carcinoma foci and autologous metastatic ones were also different. Both differences were statistically significant （P〈0.05）. Conclusion： The disequilibrium of MMP2/TIMP2 expression in carcinoma tissue with the major factor of MMP2 maybe one of the causes of cervical lymph node metastasis of PTC, in which the subcloning carcinoma cells in PTC with protein composition of high MMP2/TIMP2 ratio play an important role.

关 键 词：甲状腺肿瘤 基质金属蛋白酶-2 组织金属蛋白酶抑制剂-2 

分 类 号：R736.1[医药卫生—肿瘤]