VEGF及nm23在广西地区食管癌中的表达及其相关性研究  

Expression of VEGF and nm23 in esophageal cancer in Guangxi and the relationship between them

作　　者：苏乃伟[1] 冯旭[2] 覃家锦[2] 

机构地区：[1]广西壮族自治区妇幼保健院外科,南宁530003 [2]广西医科大学第一附属医院心胸外科,南宁530021

出　　处：《中国临床新医学》2011年第10期916-919,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西自然科学基金资助项目(编号:桂科青0640047);广西大型仪器网测试资助

摘　　要：目的探讨血管内皮细胞生长因子(vascular endothelial growth factors,VEGF)及nm23在广西地区食管癌中的表达及其与临床病理因素的关系。方法用免疫组织化学链霉素亲生物素-过氧化物酶(Streptavidin-Peroxidase,SP)法检测80例食管癌及10例正常食管黏膜组织中VEGF、nm23的表达。结果 VEGF在食管癌组织中的阳性表达显著高于正常食管黏膜组织(P<0.05);VEGF的高表达与食管癌患者的年龄、性别、组织学类型无关(P>0.05),而与分化程度、浸润程度、区域淋巴结转移情况及TNM分期有关(P<0.05)。nm23在食管癌组织中的阳性表达显著低于正常食管黏膜组织(P<0.05);nm23的表达与患者的性别、年龄、组织学类型、分化程度、浸润程度无关(P>0.05),而与有无淋巴结转移及TNM分期有关(P<0.05)。VEGF、nm23之间呈负相关(r=0.-0.520,P<0.05)。结论 VEGF在广西地区食管癌的发生、侵袭、淋巴结转移过程中起一定的作用;nm23的表达缺失与食管癌的发生密切相关,可作为评价食管癌预后良好的指标之一;VEGF、nm23在参与食管癌的发生过程中起相互抑制的作用。Objective To investigate the level of VEGF and nm23 expression in esophageal cancer and norreal esophageal mucosa in Guangxi, and detect their relationships with clinical predictive indicators. Methods The levels of VEGF and nm23 expression in 80 cases of esophageal cancer and 10 cases of normal esophageal mucosa were detected by SP immunohistochemical method. Results VEGF positive expression rate in esophageal cancer was sig- nificantly higher than that of normal esophageal mucosa （ P 〈 0. 05 ）. VEGF positive expression rate had no significant correlation with the patient＇ s age, sex, and histological type （P 〉 0. 05）, but was correlation with degree of the differ- entiation, tumors invade depth, clinical stage, and lymph node metastasis （P 〈 0. 05 ）. nm23 positive expression in e- sophageal cancer significantly lower than that of normal esophageal mucosa （P 〈 0. 05 ）. nm23 positive expression had no significant correlation with the patient＇ s age, sex, histological type, degree of the differentiation, and tumors invade depth （P 〉 0. 05）, but it was correlation with lymph node metastasis and clinical stage （P 〈 0.05）. VEGF had negative correalation with nm23 （ r = 0. - 0. 520, P 〈 0. 05 ）. Conclusion The over-expression of VEGF and The lower-expression of nm23 were significantly correlated with the carcinogenesis of esophageal cancer in Guangxi. And they had negative affection with each other.

关 键 词：食管癌 VEGF NM23 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]