颈动脉支架置入后多种蛋白分子水平变化的研究  

Level Changes of Biomarkers in Patients before and after Carotid Artery Stenting

作　　者：邹东华[1] 雷斌[1] 何世安[1] 黄振坚[1] 李婛[2] 

机构地区：[1]中国人民解放军第303医院老年病科,南宁市530021 [2]中国人民解放军第303医院神经内科,南宁市530021

出　　处：《广西医学》2011年第12期1590-1592,共3页Guangxi Medical Journal

摘　　要：目的通过检测颈动脉支架置入(CAS)前、后各蛋白标志物(PAPP-A、hs-CRP、MMP-2、MMP-9、IL-6、IL-8、TNF-α、CD40L)在血与尿中水平变化,评估颈动脉粥样斑块的稳定状态。方法一过性短暂性脑缺血(TIA)患者20例,小卒中29例,行CAS前、术后采用酶联免疫吸附法(ELISA)检测患者血与尿中各蛋白标志物水平。结果 CAS置入成功率为100%,PAPP-A、hs-CRP与IL-6水平在CAS前处于高水平,在CAS之后暂时性升高,在术后30 d下降。结论各蛋白分子的高水平提示不稳定的颈动脉粥样斑块引起的炎症反应在造成急性脑血管事件中起重要作用。Objective To evaluate the clinical significance of the sypmptomatic carotid plaques by markers （PAPP-A, hs-CRP, MMP-2, MMP-9, IL-6, IL-8, TNF-α, CD40L） in serum and urine. Methods Forty nine patients were enrolled and proceeded carotid artery steming（CAS） ,the level of markers before and after CAS were detected by enzyme-linked immunosorbent assay（ELISA）. Results Successful CAS achieved in all patients （ 100% ）. PAPP-A,hs-CRP and IL-6 were at high level before CAS,which increased after stenting and decreased after 30 days. Conclusion High level of some biomarkers indicates that inflammation caused by unstable carotid plaque plays an import role in the acute cerebral events.

关 键 词：颈动脉支架置入术 炎症介质 脑血管事件 短暂性脑缺血发作 小卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学]