兰州地区女性感染HPV及其基因类型分析  

Study on the Human Papillomavirus(HPV) Infection and Genotypes Distribution Pattern of Women in Lanzhou Area

作　　者：杨燕[1] 刘会玲[2] 虎镯 高飞艳[4] 杨毓琴[2] 

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]甘肃省人民医院妇产科,甘肃兰州730000 [3]甘肃省中医学院,甘肃兰州730000 [4]兰州大学病原生物学研究所,甘肃兰州730000

出　　处：《现代生物医学进展》2011年第21期4069-4071,共3页Progress in Modern Biomedicine

摘　　要：目的:了解兰州地区成年女性感染人乳头瘤病毒(humanpapillomavirus,HPV)及其基因类型分布状况,为本地区HPV分子流行病学研究提供理论依据。方法:利用PCR技术分别对100例妇科门诊就诊者进行HPV基因亚型检测。结果:100例样品中,HPV DNA检出率为19%(19/100),其中HPV16 DNA感染率15%(15/100),HPV58 DNA感染率3%(3/100),HPV18 DNA感染率2%(2/100),HPV 16与HPV18双重感染1例。结论:本地区成年女性HPV感染主要以HPV16多见,而HPV16与恶性肿瘤密切相关,因此对HPVDNA阳性者定期随访,有利于宫颈癌的防治。Objective： This is an epidemiological study on the distribution pattern of HPV genolypes in Lanzhou area. Methods： One hundred samples were detected for HPV genotyping by using PCR technique. Results： In 100 samples, the positive rate of HPV DNA was 19%. HPV16 DNA was 15 % （15/100）. HPV58 DNA was 3%（3/100） and HPV18 DNA was 2 %（2/100）. And one case infected both HPV16 and HPV18. Conclusion： The most prevalent HPV genotypes in Lanzhou area were HPV 16 which is closely related with the malignancy. Therefore peoples who suffered HPV DNA positive should be regularly followed-up, which is useful for the prevention and treatment of cervical cancer.

关 键 词：人乳头瘤病毒(HPV) 分型 PCR 

分 类 号：Q95-3[生物学—动物学] R737.33[医药卫生—肿瘤]