胃癌实验模型建立的研究现况  

Animal models of gastric cancer

作　　者：郭凌云[1] 刘涛[2] 李玉民[2] 

机构地区：[1]兰州大学第二临床医学院,甘肃省兰州市730030 [2]兰州大学第二医院甘肃省消化系肿瘤重点实验室,甘肃省兰州市730030

出　　处：《世界华人消化杂志》2011年第25期2609-2614,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.30870364;兰州大学中央高校基本科研业务费专项资金资助项目;No.lzujbky-2010-207;兰州大学第二医院院内基金资助项目;No.YJ2010-14~~

摘　　要：胃癌死亡率居全球恶性肿瘤第二位,占癌症总死亡率的9.7%.胃癌的发生是多步骤、多因素的,诸如致病细菌、宿主遗传因素和免疫应答等.动物模型在研究胃癌生物学行为和临床诊治过程中占有重要地位.本文将分别从微生物原位诱发、化学致癌剂原位诱发、癌细胞定植、转基因模型和计算机模拟五方面重点阐述胃腺癌模型建立的现况.Gastric cancer is the second most common cause of cancer-related mortality （9.7% of the total） worldwide. Gastric carcinogenesis is a multiplestep process that involves multiple factors, such as bacteria, immune response and host factors. Animal models play a crucial role in the research of the biological behavior, diagnosis and treatment of gastric cancer. In this article we will review current advances in the development of animal models of gastric cancer in terms of microorganism-induced models, chemical carcinogen-induced models, tumor cell implantation, genetically modified models and in silico models.

关 键 词：胃癌 动物模型 转基因 幽门螺杆菌 

分 类 号：R735.2[医药卫生—肿瘤]