初治淋巴瘤患者血浆中VEGF-C、VEGF-D、VEGFR-2及VEGFR-3的表达水平及临床意义  

Plasma Levels of VEGF-C,VEGF-D,VEGFR-2 and VEGFR-3 in Patients with Newly Diagnosed Lymphomas

作　　者：刘芳[1] 宋玉琴[2,3,4] 张晨[2,3,4] 傅志英 平凌燕 应志涛[2,3,4] 郑文[2,3,4] 王小沛[2,3,4] 谢彦[2,3,4] 林宁晶[2,3,4] 涂梅峰[2,3,4] 朱军[2,3,4] 

机构地区：[1]北京大学首钢医院血液内科,北京100144 [2]北京大学临床肿瘤学院 [3]北京肿瘤医院 [4]北京市肿瘤防治研究所淋巴肿瘤科恶性肿瘤发病机制及转化研究教育部重点实验室,北京100142

出　　处：《中国实验血液学杂志》2011年第5期1184-1188,共5页Journal of Experimental Hematology

摘　　要：本研究检测初治淋巴瘤患者血浆中血管生成相关因子VEGF-C、VEGF-D、VEGFR-2、VEGFR-3的表达水平,探讨其与淋巴瘤临床特点及预后的相关性,寻找指导淋巴瘤抗血管靶向治疗及判断预后的有价值的指标和因素。应用酶联免疫吸附测定的方法检测86例初治淋巴瘤患者血浆中VEGF-C、VEGF-D、VEGFR-2、VEGFR-3的表达水平。结果表明,多因素分析结果显示,VEGF-C在非霍奇金淋巴瘤患者中呈低表达水平,而在霍奇金淋巴瘤患者中表达水平较高;VEGFR-2在年龄>60岁淋巴瘤患者中表达较高;VEGF-D在IPI>2分的患者组中表达较低。单因素分析显示,VEGF-D在IPI>2分患者组中呈低水平表达;VEGF-D、VEGF-C在无B症状组高水平表达。因子间的关联性分析表明,VEGF-D与VEGFR-2、VEGFR-3的表达水平呈正相关。结论:VEGF-C、VEGF-D、VEGFR-2、VEGFR-3在淋巴瘤的发病中具有重要作用,可作为细化指导淋巴瘤抗血管靶向治疗、了解病情、判断预后的指标。The objective of this study was to detect the expression levels of VEGF-C,VEGF-D,VEGFR-2 and VEGFR-3 in plasma of newly diagnosed lymphoma patients,and analyze their possible relationships with clinicopathological characteristics and prognosis.The expression levels of VEGF-C,VEGF-D,VEGFR-2 and VEGFR-3 in plasma from 86 newly diagnosed lymphoma patients were detected by enzyme-linked immunosorbent assay（ELISA）.As a results,the multivariate analysis showed that VEGF-C level in non-Hodgkin′s lymphoma patients was low,but high in Hodgkin′s lymphoma patients;VEGFR-2 level was higher in patients 60 years,while VEGF-D level was lower in patients with IPI 2.The univariate analysis showed that VEGF-D level was lower in patients with IPI2,while VEGF-D and VEGF-C levels were higher in patients without B symptoms.Relationship analysis between these factors indicated that the relation of VEGF-D expression level with VEGFR-2 and VEGFR-3 was positive.It is concluded that VEGF-C,VEGF-D,VEGFR-2 and VEGFR-3 play important roles in the pathogenesis of lymphoma,and may be used as indicators of prognosis evaluation or even guide for the antiangiogenesis treatment of lymphoma.

关 键 词：淋巴瘤 VEGF-C VEGF-D VEGFR-2 VEGFR-3 

分 类 号：R733.1[医药卫生—肿瘤]