硼替佐米联合自体外周血造血干细胞移植治疗多发性骨髓瘤  

Bortezomib Combined with Autologous Peripheral Blood Hematopoietic Stem Cell Transplantation for Therapy of Patients with Multiple Myeloma

作　　者：张茜[1] 白海[1] 王存邦[1] 王美亮[1] 令亚琴[2] 吴冰[1] 

机构地区：[1]兰州军区兰州总医院血液病研究中心,甘肃兰州730050 [2]兰州大学基础医学院病理生理学研究所,甘肃兰州730000

出　　处：《中国实验血液学杂志》2011年第5期1234-1236,共3页Journal of Experimental Hematology

摘　　要：本研究探讨硼替佐米联合自体外周血造血干细胞移植(APBSCT)治疗多发性骨髓瘤(MM)的疗效。对5例MM患者行自体外周血造血干细胞移植,在APBSCT前和预处理中以及移植后的维持治疗中均应用硼替佐咪治疗。选择预处理方案为:硼替佐米(bortezomib)+马法兰(melphalan)。输注的外周血单个核细胞(PBMNC)数为4.06×108(4.09×108-4.37×108)/kg,CD34+细胞数为3.98×106(2.49×106-8.2×106)/kg。结果表明:5例患者造血完全重建,中性粒细胞(ANC)大于0.5×109/L中位时间为14(13-25)天,Plt大于50×109/L中位时间为28(21-58)天。无移植相关死亡病例,5例患者均无病生存。结论:硼替佐米联合自体外周血造血干细胞移植是治疗MM的有效方法,移植后给予硼替佐米维持治疗可能是患者延长生存时间、提高生活质量的较好方法。This study was aimed to evaluate the therapeutic efficacy of bortezomib combined with autologous peripheral blood hematopoietic stem cell transplantation（autoPBSCT） for patients with multiple myeloma（MM）.5 patients underwent autologous hematopoietic stem cell transplantation.Bortezomib treatment was supplied for patients before autoPBSCT and in the conditioning of transplantation,it was also used in maintaining treatment.Patients with transplantation adopted bortezomib plus melphalan conditioning regimen.The number of infused MNC and number of CD34＋ cells were 4.06×108（4.09×108-4.37×108）/kg and 3.98×106（2.49×106-8.2×106）/kg respectively.The results showed that hematopoiesis was reconstituted in 5 patients,with a neutrophil cell count more than 0.5×109/L at day 14（13-25 days） after transplantation and platelet count more than 50×109/L at day 28（21-41 days） after transplantation.Transplantation-associated death was not observed.5 patients were disease-free survival.In conclusion,treatment of bortezomib combined with autologous peripheral hematopoietic stem cell transplantation is an effective method for patients with multiple myeloma.Use of bortezomib after transplantation might still be favourable to MM patients,for survival prolongation and life quality improvement.

关 键 词：硼替佐米 自体外周血造血干细胞移植 多发性骨髓瘤 

分 类 号：R733.3[医药卫生—肿瘤] R979.1[医药卫生—临床医学]