Brain-derived neurotrophic factor gene transfection promotes neuronal repair and neurite regeneration after diffuse axonal injury  

作　　者：Yin Yu Xingli Zhao Jiajia Shao Qiang Shen Tao Jiang Wei WU Dong Zhu Yu Tian Yongchuan Gu 

机构地区：[1]Second Department of Neurosurgery, Bethune Third Hospital, China-Japan Friendship Hospital, Jilin University, Changchun 130031, JilinProvince, China [2]Changchun Vocational Institute of Technology, Changchun 130031, Jilin Province, China [3]Department of Neurosurgery, Jilin Provincial People＇s Hospital, Changchun 130000, Jilin Province, China [4]Department of Neurosurgery, Bethune First Hospital, Jilin University, Changchun 130021, Jilin Province, China

出　　处：《Neural Regeneration Research》2011年第25期1942-1946,共5页中国神经再生研究（英文版）

基　　金：the National Natural Science Foundation of China (Key Program and General Program), No. 10832012; 10872078

摘　　要：This study sought to assess the potential of brain-derived neurotrophic factor （BDNF） to promote neuronal repair and regeneration in rats with diffuse axonal injury, and to examine the accompanying neurobiological changes. BDNF gene transfection reduced the severity of the pathological changes associated with diffuse axonal injury in cortical neurons of the frontal lobe and increased neurofilament protein expression. These findings demonstrate that BDNF can effectively promote neuronal repair and neurite regeneration after diffuse axonal injury.This study sought to assess the potential of brain-derived neurotrophic factor （BDNF） to promote neuronal repair and regeneration in rats with diffuse axonal injury, and to examine the accompanying neurobiological changes. BDNF gene transfection reduced the severity of the pathological changes associated with diffuse axonal injury in cortical neurons of the frontal lobe and increased neurofilament protein expression. These findings demonstrate that BDNF can effectively promote neuronal repair and neurite regeneration after diffuse axonal injury.

关 键 词：diffuse axonal injury brain-derived neurotrophic factor NEURITE gene transfection neural regeneration 

分 类 号：Q421[生物学—神经生物学] Q51[生物学—生理学]