Isatin decreases Bax protein expression in the substantia nigra of a mouse model of Parkinson's disease  

作　　者：Jiguo Zhang Fang Zhang Yanlong Qiu Wang Yue 

机构地区：[1]Department of Pharmacology, Taishan Medical University, Taian 271016, Shandong Province, China [2]Department of Pharmacology Qingdao University Medicai School, Qingdao 266021, Shandong Province, China

出　　处：《Neural Regeneration Research》2011年第26期2022-2025,共4页中国神经再生研究（英文版）

基　　金：a grant from Shandong Provincial Education Department, No. J08LH54

摘　　要：The present study observed the action of 1H-indole-2, 3-dione （isatin） on Bax protein expression in the substantia nigra of a Parkinson＇s disease animal model. Parkinson＇s disease-like behaviors were induced in C57BL/6J mice treated with 1-methyl-4-phenyl-1,2, 3, 6-tetrahydropyridine （MPTP） Bax protein expression was significantly reduced in isatin （100, 200 mg/kg）-pretreated mice. Results demonstrate that isatin plays a neuroprotective role in mice treated with MPTP by down-regulating Bax protein expression.The present study observed the action of 1H-indole-2, 3-dione （isatin） on Bax protein expression in the substantia nigra of a Parkinson＇s disease animal model. Parkinson＇s disease-like behaviors were induced in C57BL/6J mice treated with 1-methyl-4-phenyl-1,2, 3, 6-tetrahydropyridine （MPTP） Bax protein expression was significantly reduced in isatin （100, 200 mg/kg）-pretreated mice. Results demonstrate that isatin plays a neuroprotective role in mice treated with MPTP by down-regulating Bax protein expression.

关 键 词：1H-indole-2  3-dione （isatin） Parkinson＇s disease 1-methyl-4-phenyl-1 2  3  6- tetrahydropyridine Bax MOUSE neurodegenerative disease neural regeneration 

分 类 号：Q78[生物学—分子生物学] TQ46[化学工程—制药化工]