医用聚氨酯材料人工食管重建的组织再生观察  

The tissue regeneration of reconstruction with artificial esophagus made of medical polyurethane

作　　者：沈冰[1] 孙磊[1] 江华[2] 郎振为[1] 王鹏[1] 滕晓英[1] 周新刚[1] 张亮[1] 王天佑[3] 

机构地区：[1]首都医科大学附属北京地坛医院病理科,北京100015 [2]山东大学附属省立医院胸外科,济南250021 [3]首都医科大学附属北京友谊医院胸外科,100050

出　　处：《临床与实验病理学杂志》2011年第10期1099-1102,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的观察医用聚氨酯材料人工食管重建时的组织再生情况,探讨其重建犬颈段食管缺损的可行性。方法纤维内镜观察人工食管及吻合口肉芽生长情况,并定期处死实验犬,取新生食管标本,进行肉眼及HE染色,镜下观察组织再生情况。结果术后食管黏膜上皮细胞可再生,3个月可覆盖缺损部位;术后1～6个月未发现食管腺体、平滑肌和横纹肌的再生;人工食管脱落后,不宜在原位时间过长,以减少对黏膜的损伤。结论医用聚氨酯材料构建的人工食管可以用于食管缺损重建,食管黏膜上皮可以再生。Purpose To observe the tissue regeneration of reconstruction with artificial esophagus made of medical polyurethane,and to study the feasibility of the new artificial esophagus in reconstruction of the cervical esophageal defect in a dog model.Methods Electric flexible esophagography was used to observe the artificial esophagus and granulation tissue,Gross and HE staining were used to observe regeneration of the esophageal tissues.Results The esophageal epithelium can regenerate,and it can cover the surface of defect in 3 months,The regeneration of gland,smooth muscle and striated muscle can not be found from 1 to 6 months after operation.After the articial esophagus ablated,it should be taken out to protect the epithelium.Conclusion The artificial esophagus made of medical polyurethane can be used to reconstruct the esophageal defect,The esophageal epithelium can regenerate.

关 键 词：人工食管 食管重建 聚氨酯 

分 类 号：R735.1[医药卫生—肿瘤] R73-36[医药卫生—临床医学]