我国人群IL-23R基因多态性与IBD的相关性分析  

Study on Relationship Between IL-23R Polymorphism and IBD Patients in China

作　　者：徐亚[1] 陈志荣[1] 陆忠凯[1] 郑家驹[1] 

机构地区：[1]南京医科大学附属苏州市立医院消化科,南京215001

出　　处：《临床消化病杂志》2011年第5期267-269,272,共4页Chinese Journal of Clinical Gastroenterology

基　　金：江苏省医学重点学科-江苏省人民医院胃肠病学开放课题资助(学科编码xk200714)

摘　　要：目的研究我国人群IL-23R基因Val362Ile和Thrl75Asn单核苷酸多态性,分析其与炎症性肠病(IBD)的相关性。方法采用PCR扩增和测序的方法对198例IBD患者和100例健康对照者IL-23R基因Val362Ile和Thrl75Asn多态性进行分析,计算其等位基因的表现频率,结合临床资料分析其多态性与IBD的相关性。结果 (1)IBD中克罗恩病患者IL-23R Val362Ile等位基因A的表现频率为2.7%,溃疡性结肠炎组为2.4%,对照组为2.0%,3组无明显统计学差异(P>0.05)。(2)IBD及对照组中均无Thrl75Asn等位基因A表现,相应位点均表现为C。结论我国人群IL-23R Val362Ile单核苷酸多态性与IBD无明显相关性,未发现Thrl75Asn等位基因A。Objective To analyze the single nucleotide polymorphism of IL-23R and to detect the relationship with inflammatory bowel disease（IBD） in China. Methods The polymorphism of IL-23R Va1362Ile and Thr175Asn were detected with PCR and sequenced in 198 IBD and 100 healthy controls. The allele frequencies were calclated and analyzed to detect the relationship with IBD. Results （ 1 ） The allele frequency of A in IL-23R Va1362Ile of Chron＇ s disease（CD） was 2.7%, and the allele frequencies of ulcerative colitis（UC） and control were 2.4% and 2.0% respectively. There was no statistical differ- ence among the three groups（P 〉0.05）. （2）The allele A in IL-23R Thr175Asn was not found in all the three groups. And the allele of the three groups was all presented with C. Conclusion The polymorphism of Va1362Ile in IL-23R has no association with IBD in China and the allele A of Thr175Asn is not found in Chinese.

关 键 词：炎症性肠病 IL-23R 单核苷酸多态性 

分 类 号：R574[医药卫生—消化系统]