脐血干细胞移植治疗脑出血的疗效分析  

Therapeutic Efficacy of Umbilical Cord Blood Stem Cells on Cerebral Hemorrhage

作　　者：李秀云[1] 张国华[2] 

机构地区：[1]内蒙古医学院研究生学院 [2]内蒙古医学院附属医院神经内科

出　　处：《中华全科医学》2011年第11期1724-1725,共2页Chinese Journal of General Practice

摘　　要：目的探讨脐血干细胞移植治疗脑出血的方法、疗效、安全性及可行性。方法 26例脑出血患者,其中男性16例,女性10例;年龄26～83岁,平均(56.00±5.34)岁,脑出血后遗症15例,脑出血急性期11例。采用鞘内注射法将体外分离出的脐血干细胞移植到脑出血患者的蛛网膜下腔,并随访观察3个月,采用欧洲卒中量表评分标准、独立功能评分标准进行评分评价其疗效,对随诊患者行头颅电子计算机体层扫描、肺部X射线片、心电图及血液生化检查,评价其安全性。结果 26例行鞘内注射中3例无效,23例有效。移植3个月后26例患者欧洲卒中量表评分标准及独立功能评分标准评分均较移植前明显提高,欧洲卒中量表评分标准:(69.80±10.71)分、(60.80±15.68)分,P<0.05,独立功能评分标准:(94.76±14.42)分、(90.20±16.75)分,P<0.05;急性期移植患者移植后独立功能评分为93.90±11.54,77.72±11.37(Z=-2.940,P=0.003);后遗症移植患者移植后独立功能评分为94.35±16.69,90.20±16.75(Z=-3.309,P=0.001),差异均有统计学意义。结论鞘内注射移植脐血干细胞治疗脑出血有效可行且急性期优于后遗症期。Objective To investigate the method,safety,efficacy and feasibility of human umbilical cord blood stem cells transplantation in treating the brain hemorrhage.Methods Among 26 patients with the brain hemorrhage,there were 16 males and 10 females,aged from 26 to 83 years（average 56.00±5.34）,11 cases were in the acute phase of cerebral hemorrhage,15 with the sequelae of brain hemorrhage.Stem cells cultured from human umbilical cord blood were transplanted into all patients through lumbar acupuncture into subarachnoid space.After 3 months follow-up,the European Stroke Scale（ESS） and Functional independence measure（FIM） were adopted to evaluate the effect of transplantation.Meanwhile,CT,MRI,lung-X-ray,electrocardiogram（ECG） and blood biochemical were also measured to evaluate the side effects of the transplantation.Results Among 26 patients who entered the result analysis,the treatments were effective in 23 cases.3 months after transplantation,the scores of ESS and FIM were significantly improved.ESS：from（69.80±10.71） to（60.80±15.68）,P0.05;FIM：from（94.76±14.42） to（90.20±16.75）,P0.05.For the patients with acute period transplantation,the independent functional score were（93.90±11.54） and（77.72±11.37）（Z=-2.940,P=0.003）;while for the patients with sequela period transplantation the independent functional score were（94.35±16.69） and（90.20±16.75）,（Z=-3.309,P=0.001）.The differences between the two groups were significant.Conclusion Transplantation of human umbilical cord blood stem cells by lumbar injection is an effective and feasible way to treat the brain hemorrhage,and the effects of the treatment in the acute period is superior than that in the sequela period.

关 键 词：脐血干细胞 脑出血 细胞移植 

分 类 号：R743.34[医药卫生—神经病学与精神病学]