19种南药提取物体外抗单纯疱疹病毒I型活性研究  

Investigation on Anti-herpes Simplex Virus Type I Activity of Extracts from Southern Chinese Herbs in vitro

作　　者：李深[1] 赖志才[1] 瞿畅[1] 张美英[1] 张颖君[2] 杨崇仁[2] 王一飞[1] 

机构地区：[1]暨南大学生物医药研究开发基地,广东广州510632 [2]中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,云南昆明650204

出　　处：《时珍国医国药》2011年第3期539-540,共2页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金.广东省人民政府自然科学联合基金(No.U0632010)

摘　　要：目的从19种南药提取物中筛选具有抗单纯疱疹病毒I型活性的成分。方法采用细胞病变效应法(Cytopathogen-ic effect,CPE)测定不同提取物的细胞毒性及抗HSV-I活性。结果从19种南药提取物中找到了5种含有抗单纯疱疹病毒I型的活性成分。结论对这5种提取物及其相关化合物的进一步研究,有希望开发出抗单纯疱疹病毒I型的新药。Objective To screen the active extracts of anti-herpes simplex virus type Ⅰ activity from nineteen southern Chinese herbs. Methods The method of Cytopathogenic effect assay was adopted to measure cytotoxicity and anti-HSV-1 activity of different extracts. Results Five active extracts of anti-herpes simplex virus type Ⅰ activity were found in the nineteen southern Chinese herbs. Conclusion The five extracts and related compounds should be studied furtherly.

关 键 词：南药 单纯疱疹病毒I型 细胞病变效应法 活性 

分 类 号：R285.5[医药卫生—中药学]