奥美沙坦对ob／ob小鼠血浆脂联素水平影响的研究  

Effects of olmesartan on the serum adiponectin level of ob / ob mice

作　　者：于彦伟[1] 奚宁宁 尚建欣[1] 冯薇[1] 王召军[1] 曲秀芬[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院心血管内科,150001 [2]黑龙江省康复医院

出　　处：《国际免疫学杂志》2011年第6期400-403,共4页International Journal of Immunology

基　　金：黑龙江省教育厅科学技术研究项目（11541170）

摘　　要：目的观察ob／ob小鼠不同组间血浆脂联素浓度的变化以及奥美沙坦干预后脂联素浓度的变化。方法以ob／ob小鼠为对象，分为三组：①ob／ob小鼠空白组；②ob／ob小鼠高脂组；③ob／ob小鼠奥美沙坦组，①喂以普通饲料；②③喂以高脂饮食，10周后，早期动脉粥样硬化成模后，给与①②组安慰剂及③组奥美沙坦分别进行干预，10周后分别测定三组小鼠体脂肪含量，血糖，甘油三酯，总胆固醇，血清脂联素水平。结果ob／obl／小鼠高脂组脂联素水平低于ob／ob小鼠（P〈0．05），奥美沙坦组脂联素水平高于ob／ob小鼠高脂组及ob／ob小鼠空白组（P〈0．05）且奥美沙坦组体脂肪含量，甘油三酯，总胆固醇均低于空白组和高脂组（P〈0．05）。结论奥美沙坦能提高活体内脂联素水平，改善血脂水平。Objective Observation of plasma adiponectin concentrations of ob / ob mice in different groups and changes after the olmesartan intervention. Methods ob / ob mice were divided into three groups： （1） blank control group; （2） high-fat group; （3） olmesartan group. Mice in the control group were fed with ordi- nary diet, while the others were fed with high-fat diet. Early atherosclerosis was detected pathologically after 10 weeks in high-fat fed mice. According, mice in two group （2）, （3） were treated with placebo, olmesartan. Lipid , blood sugar , triglyceride , total cholesterol serum adiponectin levels and pathological eximination were per- formed after 10 weeks Results After 10 weeks treatment, serum adiponectin concentration in group （2） were significantly lower than that in group （1） （P 〈 0.05 ）. Serum adiponectin levels in group （3）were significantly higher than that in group （1） and （2）（P 〈 0.05 ）. Moreover, glycogen deposition and lipidosis was significantly decreased in group （3） when compared to group （1） and （2） （P 〈：0.05 ）. Conclusion Olmesartan can increase adiponectin levels in vivo, and lower blood lipid levels.

关 键 词：动脉粥样硬化 脂联素 OB/OB小鼠 奥美沙坦 

分 类 号：R[医药卫生]