磁共振梯度双回波化学位移成像定量诊断脂肪肝的临床应用  

Clinical application of MR dual-echo chemical shift gradient-echo imaging in quantitative diagnosis of fatty liver

作　　者：徐东风[1] 施蒋巍[1] 沈莉[1] 戴鸿志[1] 赵雪文 刘利[1] 沈一易 刘柯柯[1] 李曼[1] 

机构地区：[1]吴江市第一人民医院影像科,江苏吴江215200

出　　处：《实用放射学杂志》2011年第10期1492-1494,1503,共4页Journal of Practical Radiology

基　　金：苏州市科技发展计划项目（编号：SYSD2010097）.

摘　　要：目的 探讨磁共振梯度双回波化学位移成像定量诊断脂肪肝的临床应用。方法20例弥漫性脂肪肝病例，周期行CT及磁共振梯度双回波化学位移成像，分别对肝VI段及IV段（Couinaud法）选取同一部位感兴趣区进行测量。正反相位信号强度差／正相位信号强度（SIP—SOP）／SIP及正反相位信号强度差SIP—SOP与肝／脾CT值比值（L／S）进行Spearman相关性分析及建立直线同归方程。根据L／S评价脂肪肝程度的标准，计算（SIP—SOP）／sIP、SIP-SOP评价脂肪肝程度的标准。结果（SIP-SOP）／SIP、SIP-SOP与L／S的相关系数分别是r=-0．908及r=-844（P〈0．01），回归方程分别是y=-1．751x＋1．278及Y=-1．s8×10-3x＋1．005，（SIP-SOP）／sIP诊断脂肪肝的标准为：轻度0．329〉（SIP-SOP）／sIP≥0．159、中度0．444〉（SIP-SOP）／sIP≥0．329．重度为（SIP-SOP）／sIP≥0．444。SIP-SOP诊断脂肪肝的标准为轻度：193．0〉SIP—SOP≥3．2，中度：319．6〉sIP—SOP≥193．0．重度：sIP—sOP≥319．6。结论磁共振梯度双回波化学位移技术与CT定量诊断脂肪肝具有较好的相关性，可成为临床定量诊断脂肪肝的一种简单、有效方法。Objective To evaluate the clinical application of MR dual-echo chemical shift gradient-echo imaging in quantitative diagnosis of fatty liver. Methods 20 patients with diffused fatty liver underwent CT and MR dual-echo chemical shift gradient-echo imaging simutaneously. The liver segments （Couinaud} VI and IV were selected separately at region of interest （ROI） in the same site to study the relationship between（ SIP-SOP ）/SIP, SSIP-SOP and L/S （ SIP ： signal intensity of in-phase, SOP ： signal intensity of outphase, L/S： CT attenuation ratio of liver to spleen ） using Spearman correlation coefficient and linear regression equation. The diagnostic criteria of fatty liver using（SIP-SOP ）/SIP and SIP- Sop were calculated refer to the criteria of L/S. Results （SIP-SOP ）/SIP and SIP-SOP had significant relationship with L/S（ r=-0. 908 and r=- 0. 844, P〈0.01 respectively）, linear regression equations were y=1. 751x＋ 1. 278 and y=-1.58× 10-3 x＋1. 005 respectively. The diagnostic criteria of fatty liver for （SIP-SOP ）/Sw were as following, mild level：0. 329〉 （ SIP- SoP ）/SIP≥0. 159, moderate level： 0. 444〉 （ SIP- SOP ）/SIP≥0. 329 and severe level： （ SIP -SOP ）/SIP≥0. 444,and the diagnostic criteria for SIP-Sop were as following,mild level： 193.0〉SIp-Sop3.2,moderate level：319.6 % （ Sip- Sop ） ≥ 193.0 and severe level： （ SIp- Sop ） ≥319. 6. Conclusion MR dual-echo chemical shift gradient-echo imaging is of significant relationship with CT in quantitative diagnosis of fatty liver, it is an easy and effective method in clinical application in quantitative diagnosis of fatty liver.

关 键 词：肝脏 脂肪肝 磁共振成像 体层摄影术 X线计算机 

分 类 号：R575[医药卫生—消化系统] R445.2[医药卫生—内科学]