石辛牙痛口含片对智齿冠周炎病人冠周盲袋细菌的抑制作用  

Effects of Shixinyatong buccal tablets against bateria in pericoronal pocket of patients with pericoronitis

作　　者：吴军正 杨聚才 安银东 李元聪[2] 胡开进 卜献春[3] 关素敏 温德升 

机构地区：[1]第四军医大学口腔医院,陕西西安710032 [2]湖南中医学院第一附属医院,湖南长沙410007 [3]湖南省中医药研究院附属医院,湖南长沙410006

出　　处：《牙体牙髓牙周病学杂志》2011年第10期577-580,576,共5页Chinese Journal of Conservative Dentistry

基　　金：国家中小企业创新基金(05C26214201065)

摘　　要：目的:探讨石辛牙痛口含片治疗胃火牙痛(智齿冠周炎)过程中对冠周盲袋细菌的抑制作用。方法:运用随机双盲双模拟平行对照多中心临床试验,纳入符合胃火牙痛(智齿冠周炎)试验组(石辛)、对照组(牛黄)各120例。就诊当天对受试者常规冠周袋冲洗。石辛组病人含化石辛牙痛口含片,0.6 g×2,4次/d;口服牛黄解毒片赋形剂,0.3 g×3,3次/d。牛黄组病人口服牛黄解毒片,0.3 g×3,3次/d;含化石辛牙痛口含片赋形剂,0.6 g×2,4次/d,疗程5 d。用药前后各进行1次冠周盲袋细菌检测,按Bergey's系统细菌学鉴定标准鉴定菌属名称。结果:符合方案数据集(PPS)在石辛组和牛黄组各112和111例受试者。治疗后石辛组和牛黄组总菌落数(CFU/mL)减少率(%)分别为59.05±25.64和59.67±27.25。石辛组和牛黄组的细菌清除率分别为75.89%和78.37%。全部厌氧菌的总菌落数(CFU/mL)减少率(%)分别为83.48±26.87和82.34±24.61,全部兼性厌氧菌的总菌落数(CFU/mL)减少率(%)分别为41.57±23.89和40.86±30.47。鉴定的16种主要细菌菌落数(CFU/mL)减少率(%)两组之间差异均无统计学意义(P>0.05)。结论:石辛牙痛口含片和牛黄解毒片都有抑制盲袋细菌的作用,二者无显著差异。AIM： To study the effects of Shixinyatong buccal tablets（SBT） against bateria in pericoronal pocket of patients with pericoronitis.METHODS： Randomized,double-blinded,double-imitated,parallel-controlled and multi-centered clinical study was employed.One hunered and twenty cases of gastropyretic toothache（pericoronitis） was enroled in the experimental group（SBT group） and another 120 in control（BBPD group）.Pericoronal pocket rinsing was performed for each case at the first visit.Patients in SBT group were treated by SBT,0.6g×2,4/d and oral adiministration of the vehicle of bovine bezoar pill for detoxification（BBPD）,0.3g×3,3/d.Patients in BBPD group were treated by oral adiministration of BBPD,0.3g×3,3/d and the vehicle of SBT,0.6g×2,4/d,respectively.The bateria in pericoronal pocket of each case were examined and classified by Bergey′s standard before and after treatment.RESULTS： In per protocol set（PPS） there were 112 cases in SBT group and 111 in BBPD group.After treatment,the decreacse rates（%） of total bacteria（CFU/mL） were 59.05±25.64 and 59.67±27.25（P〉0.05）,the clearance rates（%） of the total bacteria in pericoronal pocket in SBT and BBPD groups were 75.89 and 78.37（P〉0.05）,the decreacse rates（%） of total anaerobic bacteria（CFU/mL） were 83.48±26.87 and 82.34±24.61（P〉0.05）,the decrease rates（%） of total facultative anaerobe（CFU/mL） were 41.57±23.89 and 40.86±30.47（P〉0.05）,respectively.The decrease rates（%） of 16 identified bacteria（CFU/mL） were not statistically defferent（P〉0.05）.CONLUSION：Shixinyatong buccal tablet and bovine bezoar pill for detoxification have similar antiseptic effects against baterira in pericoronal pocket of patients with pericoronitis.

关 键 词：石辛牙痛口含片 牛黄解毒片 胃火牙痛 智齿冠周炎 

分 类 号：R782.3[医药卫生—口腔医学]