Gli1蛋白在乳腺癌组织中的表达及意义  

Expression and significance of Gli1 in breast carcinoma

作　　者：王自全[1] 张兰胜[1] 韩正祥[2] 

机构地区：[1]徐州医学院第二附属医院肿瘤内科,江苏徐州221006 [2]徐州医学院附属医院肿瘤内科,江苏徐州221006

出　　处：《中国医药科学》2011年第20期18-19,共2页China Medicine And Pharmacy

摘　　要：目的探讨Gli1在乳腺癌组织中的表达及其意义。方法采用免疫组化S-P方法测定64例乳腺癌组织以及52例癌旁正常乳腺组织、42例乳腺纤维腺瘤组织中Gli1蛋白的表达情况。结果 Gli1蛋白在癌旁乳腺组织及纤维腺瘤组织中不表达或弱表达,在乳腺癌组织中的明显表达,差异有统计学意义（P〈0.05）;Gli1蛋白在乳腺癌患者腋窝淋巴结有无转移中的表达差异有统计学意义（P〈0.05）,在Ⅲ期乳腺癌中的阳性表达率高于Ⅰ~Ⅱ期乳腺癌（P〈0.05）。结论 Gli1蛋白与乳腺癌组织的发生发展有一定的关系。Objective To investigate the Gli1 protein expression in breast cancer organization and its significance. Methods Tissues of 64 breast carcinoma and 52 latero-carcinoma and 42 fibroadenoma were assembled,the expression of Gli1 proteins was detected by.using immunohistochemical SP method. Results Only weak expression,if any,of Gli1 proteins in latero-carcinoma and fibroadenoma,but in breast carcinoma,the expression of Gli1 proteins was significantly Gli1 protein in breast cancer axillary lymph node metastasis in patients with the expression of a significant difference（P 0.05）,stage Ⅲ in breast cancer,the positive expression rate in Ⅰ-Ⅱ breast cancer （P 0.05）. Conclusion Gli1 expression is correlated with breast tumorigenesis closely.

关 键 词：乳腺癌 GLI1蛋白 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤]