溴代白杨素衍生物合成及其抗癌活性  

Synthesis and Anticancer Activity of Bromochrysin Derivatives

作　　者：郑兴[1] 王小平[1] 刘运美[1] 郭玉[1] 罗星[1] 尹松[1] 代琴[1] 朱琼妮[1] 廖端芳[2] 

机构地区：[1]南华大学,湖南衡阳421001 [2]湖南中医药大学,湖南长沙410208

出　　处：《时珍国医国药》2011年第6期1343-1344,共2页Lishizhen Medicine and Materia Medica Research

基　　金：国家教育部科研重点项目(No.2008097);湖南省自然科学基金(No.07JJ6157)

摘　　要：目的研究溴取代白杨素衍生物的体外抗癌活性。方法合成溴取代的白杨素衍生物,并通过MTT法检测其对人急性粒细胞性白血病（HL-60）细胞、人结肠癌（HT-29）细胞和人胃癌（SGC-7901）细胞增殖抑制作用。结果合成了6个溴取代白杨素衍生物。结论溴取代白杨素衍生物具有良好的抗癌活性（IC50=0.85~11.60μmol/L）。Objective To study the anticancer activity of bromochrysin derivatives.Methods Bromochrysin derivatives were prepared and their anticancer activity in vitro was evaluated by the standard MTT method.Results Six bromochrysin derivatives were synthesized.Conclusion Bromochrysin derivatives possess potent anticancer activity（IC50 = 0.85~11.60 μmol/L）.

关 键 词：溴代 白杨素 衍生物 抗癌活性 

分 类 号：R284.1[医药卫生—中药学]