膀胱尿路上皮癌组织中AIB1和PI3K的表达及意义  

Expression of AIB1 and PI3K protein in human bladder urothelial carcinoma tissues

作　　者：廖冰[1] 韦锦焕[2] 陈炜[2] 赵红伟[2] 曹嘉正[2] 方咏[2] 罗俊航[2] 

机构地区：[1]中山大学附属第一医院病理科,广州510080 [2]中山大学附属第一医院泌尿外科,广州510080

出　　处：《现代泌尿生殖肿瘤杂志》2011年第5期297-300,共4页Journal of Contemporary Urologic and Reproductive Oncology

基　　金：国家自然科学基金资助项目(30900539);广东省科技计划项目(2008B030301112);广东省自然科学基金资助项目(8151008901000149)

摘　　要：目的应用免疫组化方法检测膀胱尿路上皮癌组织中AIB1和PI3K的表达,分析两者表达的相关性及其临床病理学意义。方法收集52例行全膀胱切除术治疗的膀胱尿路上皮癌患者手术标本,采用免疫组化法检测52例肿瘤组织、10例非肿瘤组织中的AIB1和PI3K表达情况。结果 AIB1和PI3K阳性表达率在膀胱尿路上皮癌组织明显高于非癌膀胱组织,AIB1表达与患者性别、年龄、病理分级、肿瘤数目等没有相关性。T3期膀胱癌AIB1阳性表达率显著高于T1、T2期膀胱癌(P=0.044)。AIB1与PI3K的表达呈正相关(r=0.302,P=0.030)。结论 AIB1是膀胱癌预后不良的分子标记;PI3K/AKT信号通路可能是AIB1促癌作用的重要机制。Objective To investigate the expressions of AIB1 and PI3K protein in bladder urothelial carcinoma and to determine the correlation between two protein expressions.Methods Fifty two cases of bladder urothelial carcinoma and ten normal tissues of bladder were collected,from 52 patients underwent radical cystectomy.The level of AIB1 and PI3K protein expressed in these tissues were detected by immunohistochemical method.Results The positive rates of AIB1 and PI3K protein in bladder urothelial carcinoma were significantly higher than that of the normal tissues.No correlation was found between the expression of AIB1 protein and the clinicopathological features of gender,age,pathological grade,and multiplicity.The positive rate of AIB1 in T3 tumors was significantly higher than that in T1、T2（P=0.044）.There was a positive correlation between the expression of AIB1 and PI3K （r=0.302,P=0.030）.Conclusions The overexpression of AIB1 is a molecular marker for poor prognosis of patients with bladder urothelial carcinoma.PI3K/AKT pathway might be an important mechanism of AIB1 function.

关 键 词：膀胱肿瘤 AIB1 PI3K 免疫组织化学 

分 类 号：R737.14[医药卫生—肿瘤]