胃癌CT征象与组织分化及p53、Ki67表达的相关性  

Correlation of CT Presentation with Histo-differentiation and p53 and Ki67 Expressions in Gastric Cancer

作　　者：王景宇[1] 冬冬[1] 戴春来[1] 王淑清[1] 周丹丹[1] 

机构地区：[1]吉林大学第一临床医院放射线科,长春130021

出　　处：《中国医学科学院学报》2011年第5期555-559,共5页Acta Academiae Medicinae Sinicae

摘　　要：目的探讨胃癌CT征象与病理组织分化及p53、Ki67表达的关系,为临床提供更多信息。方法使用多层螺旋CT机对158例胃癌患者行平扫、增强扫描,纪录CT观察指征(CT图像上最大径及厚度、强化差值、浆膜侵犯、淋巴结及远处转移),免疫组织化学和反转录多聚酶链式反应测定p53、Ki67的表达。结果组织分化与CT图像上病灶厚度(χ2=5.554,P=0.018)、强化差值(χ2=5.273,P=0.022)、淋巴结转移(χ2=6.061,P=0.014)具有相关性;p53表达与淋巴结转移具有相关性(χ2=5.028,P=0.025);Ki67表达与CT图像肿瘤厚度(χ2=5.674,P=0.017)、淋巴结转移(χ2=5.028,P=0.025)具有相关性。结论螺旋CT做为一种简便、无创的检查方法,可以初步估计组织分化、p53及Ki67的表达。Objective To study the relationship between spiral CT findings and histological differentiation and expressions of p53 and Ki67 in gastric carcinoma.Methods Triphasic spiral CT was performed in 158 patients.CT findings included maximal diameter and thickness of tumor in three dimensional CT images,degree of enhancement,muscous situation,lymph nodes,and visceral metastasis were recorded.The expressions of p53 and Ki67 were detected with immunohistochemistry and reverse transcription polymerase chain reaction.Results The thickness of tumor（χ^2=5.554,P=0.018）,degree of enhancement（χ^2=4.978,P=0.026）,and lymph nodes metastasis（χ^2=6.061,P=0.014） in the three dimensional CT images were significantly correlated with tumor histological differentiation.Lymph nodes metastasis was significantly correlated with the expression of p53（χ^2=5.028,P=0.025）.The expression of Ki67 was significantly correlated with the thickness of tumor（χ^2=5.674,P=0.017） and lymph nodes metastasis（χ^2=5.028,P=0.025）.Conclusion Multi-slice CT is a simple and noninvasive technique,and can be used for assessing the histological differentiation of gastric cancer as well as the expressions of p53 and Ki67 before the operation.

关 键 词：CT征象 胃癌 组织分化 P53 KI67 

分 类 号：R735.2[医药卫生—肿瘤]