特比萘芬和伊曲康唑治疗原发性皮肤曲霉病2例疗效观察  

Clinical Efficacy Observation in Treatment of Primary Cutaneous Aspergillosis with Tebinafine and Itraconazole: Two Case Reports

作　　者：尤海燕[1] 李晓捷[1] 刘冰梅[1] 杨晶[1] 张美莲[1] 尤刚[1] 

机构地区：[1]黑龙江省医院皮肤科,黑龙江哈尔滨150001

出　　处：《中国皮肤性病学杂志》2011年第11期858-860,882,共4页The Chinese Journal of Dermatovenereology

摘　　要：分别应用特比萘芬、伊曲康唑治疗2例皮肤曲霉病,并对其治疗前后真菌学和组织病理改变进行对比观察。例1,男,38岁,躯干部出现多发性坏死性溃疡2个月。通过真菌学、组织病理和扫描电镜观察确诊为黄曲霉所致原发性皮肤曲霉病。口服特比萘芬,500mg/d,治疗4周后治愈。例2,女,28岁,双手背、左跟腱部发生数个结节及坏死性溃疡8个月。实验室检查方法和诊断基本同例1。给予伊曲康唑口服,400mg/d,5周后显著好转,将剂量减至200mg/d,维持治疗至3个月后临床痊愈。例1、例2于治疗后做真菌分离培养均未见生长,组织病理复查病灶亦无真菌。To cases of cutaneous aspergillosis treated with terbinafine and itraconazole respectively are reported. The mycology and histopathology changes in the patients before and after the treatment were observed. Case 1 was a 38-year-old man witil multiple necivtic ulcer on trunk tor two months, who was diagnosed as having primary cutaneous aspergillosis due to aspergillus flares by mycology histopathology and scanning electron microscopy. After the administration of oral tebinafine, 500mg a day, for 4 weeks the patient was eared. Case 2 was a 28-year-old woman with several nodules and necrotic ulcer on the backs of her two hands and left Achilles tendon area for 8 months. Both case 1 and case 2 have almost the same laboratory results and diagnosis. Case 2 was treated with oral itraconazole, 400mg a day, for 5 weeks and alter the condition was obviously improved, itraconazole was reduced to 200mg per day, lasting for 3 months. The patient was cured. Mter the treatment, fimgi were not grown from the lesions of the two patients in isolated culture and fungus elements were not found by histopathology.

关 键 词：皮肤曲霉病 原发性 黄曲霉 特比萘芬 伊曲康唑 

分 类 号：R519.8[医药卫生—内科学]