Consortium for the Human Information and Neurocognitive Endophenotype (CHINE) in China's Mainland: An example from neurological soft signs for neuropsychiatric disorders  

作　　者：CHAN Raymond C K 

机构地区：[1]Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences

出　　处：《Chinese Science Bulletin》2011年第32期3409-3415,共7页

基　　金：supported partially by the Key Laboratory of Mental Health,Institute of Psychology, Project-Oriented Hundred Talents Programme (O7CX031003);the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-YW-R-131);National Natural Science Foundation of China (30770723);National Outstanding Young Investigator Award (81088001);a grant from National Basic Research Programme of China (973 Program) (2007CB512302)

摘　　要：Increasing efforts to identify alternate expressions of neuropsychiatric disorders that are broader than the DSM or ICD diagnostic criteria needed to diagnose them reflects a growing consensus that multidimensional expressions of neuropsychiatric disorders may advance the search for underlying etiological or modulatory factors. Endophenotypic research can be considered to be one of the most promising strategies to bridge the gap between genomic complexity and the phenotypic heterogeneity observed in neuropsychiatric disorders. However, the majority of endophenotype studies were limited to our western counterparts, very little has been done and initiated by scholars in China's Mainland. In this paper, we urge the need to establish a potential central consortium for endophenotypes to study neuropsychiatric disorders in China's Mainland. In particular, we illustrate a potential example of neurological soft signs in following the steps for building the consortium.Increasing efforts to identify alternate expressions of neuropsychiatric disorders that are broader than the DSM or ICD diagnostic criteria needed to diagnose them reflects a growing consensus that multidimensional expressions of neuropsychiatric disorders may advance the search for underlying etiological or modulatory factors. Endophenotypic research can be considered to be one of the most promising strategies to bridge the gap between genomic complexity and the phenotypic heterogeneity observed in neu- ropsychiatric disorders. However, the majority of endophenotype studies were limited to our western counterparts, very little has been done and initiated by scholars in China's Mainland. In this paper, we urge the need to establish a potential central consortium for endophenotypes to study neuropsychiatric disorders in China's Mainland. In particular, we illustrate a potential example of neu- rological soft signs in following the steps for building the consortium.

关 键 词：精神障碍 中国大陆 神经 茅根 信息 人力 多维表达式 ICD 

分 类 号：R741[医药卫生—神经病学与精神病学]