小型猪用生物拉链的生物相容性评价  

Evaluation for biocompatibility of the biological zipper for the miniature pig

作　　者：余琛琳[1] 刘志学[1] 马雷[1] 蔡丽萍[1] 徐晨[1] 崔淑芳[1] 

机构地区：[1]第二军医大学训练部实验动物中心,上海200433

出　　处：《重庆医科大学学报》2011年第9期1077-1080,共4页Journal of Chongqing Medical University

基　　金：上海市科技发展基金资助项目(编号:08140901400;09140903100)

摘　　要：目的:研究设计小型猪腹壁拉链动物模型用生物拉链,并检测、评价其生物相容性。方法:结合小型猪体型和生活习性特点、以及动物外科手术实验要求,设计生物拉链外形,并依据国家标准(GB/T 16886.10-2005/ISO 10993-10:2002),采用皮肤刺激性试验和皮肤致敏试验测定其生物相容性。结果:生物拉链具备操作简便、节省手术操作时间、减少创口感染等诸多优点,并成功获得国家知识产权专利(专利号:200920207646.1);皮肤刺激性试验未出现皮肤刺激反应;皮肤致敏试验未出现皮肤致敏反应。结论:生物拉链设计合理,具有良好的生物相容性,为小型猪腹壁拉链模型动物在教学、科研和临床中的推广应用奠定了良好的基础。Objective：To design the biological zipper for the animal model of abdominal wall zipper of the miniature pig and test its biocompatibility.Methods：The shape of the biological zipper was designed in line with the size and living habits of the miniature pig,and the demands for animal surgery.According to the series standards of GB/T16886.10-2005,the skin irritation and the skin sensitization experiments were carried out on miniature pigs.Results：The constructed biological zipper was easy to operate,could save operation time and reduce wound infections,and it has successfully obtained the state intellectual property patent（patent number：200920207646.1）.No irritation on the integral or damaged skin of miniature pig was observed.Sensitization effect on the skin of miniature pig was not found.Conclusion：The biological zipper with reasonable design and satisfactory biocompatibility lays a good foundation for the animal model of abdominal wall zipper of the miniature pig in teaching,research and clinical application.

关 键 词：生物拉链 皮肤刺激 皮肤致敏 生物相容性 

分 类 号：R-332[医药卫生]