比较GGT-H亚型和AFP检测对评估原发性肝癌根治术后生存的价值  

Relationship between GGT mRNA-H subtype expression and the survival of HCC patients after radical mastectomy

作　　者：王莹莹[1] 曹虹[2] 朱中元[1] 谢勇[1] 

机构地区：[1]海南省农垦总医院检验科,海口570311 [2]中南大学湘雅二医院检验科,长沙410011

出　　处：《重庆医科大学学报》2011年第9期1116-1118,共3页Journal of Chongqing Medical University

摘　　要：目的:比较谷氨酰转肽酶(γ-glutamyl trasnpeptidase,GGT)-H亚型和甲胎蛋白(Alpha-fetoprotein,AFP)检测对评估原发性肝癌(Hepatocellular carcinoma,HCC)根治术后生存的价值。方法:67例HCC患者于手术当日晨起空腹抽外周静脉血10ml,应用PCR法检测GGT mRNA-H亚型的表达,并采用放射免疫测定法检测AFP水平,评估两者对评估HCC根治术后生存的预测价值。结果6:7例患者1、3、5年累积生存率分别为71.5%、35.1%和18.7%,其中GGT mRNA-H亚型表达阴性者为79.5%、42.3%和22.1%,而表达阳性者为65.5%、24.1%和11.7%(χ2=3.014,P=0.021)。而AFP<400μg/L的HCC患者术后1、3、5年累积生存率分别为76.3%、44.6%和23.9%,AFP>400μg/L的1年、3年、5年累积生存率分别为62.1%、21.1%和13.2%(χ2=2.697,P=0.035)。Cox模型显示GGT mRNA-H对预后的影响也较AFP大(OR=1.672 vs OR=1.145)。结论:外周血细胞GGTmRNA-H亚型表达的检测是评估HCC术后预后的可靠指标,并要优于AFP的检测。Objective：To evaluate the relationship between GGT mRNA-H subtype expression and the survival of HCC patients after radical mastectomy.Methods：67 patients with HCC were enrolled in this study.On the surgery day,10 ml peripheral venous blood was drawn from each patient in the morning,PCR used to detect the GGT mRNA-H subtype expression.AFP level were also detected by radioimmunoassay.Results：The 1,3,5-year survival rates of the 67 HCC patients were 71.5%,35.1% and 18.7% respectively,of which 79.5%,42.3% and 22.1% were found respectively in the negative expression of GGT mRNA-H subtype,and 65.5%,24.1% and 11.7% found respectively in the positive expression（χ2=3.014,P=0.021）.Cox model showed that GGT mRNA-H had more impact on prognosis than the AFP（OR=1.672 vs OR=1.145）.Conclusion：Peripheral blood cell GGTmRNA-H subtype expression detection is a reliable indicator to predict the prognosis of primary liver cancer patients,and it＇s better than AFP testing.

关 键 词：原发性肝癌 根治术 预后 谷氨酰转肽酶H亚型 甲胎蛋白 

分 类 号：R735.7[医药卫生—肿瘤]