p53基因第72密码子基因多态性和蒙古族妇女宫颈癌的相关性分析  

Study on the Correlation between p53 Codon 72 Polymorphism and Cervical Cancer in Mongolian Women Population

作　　者：杨敏[1] 徐景杰[1] 

机构地区：[1]武警内蒙古总队医院妇产科,呼和浩特010040

出　　处：《医学综述》2011年第21期3352-3354,共3页Medical Recapitulate

摘　　要：目的探讨p53基因第72密码子基因多态性与蒙古族妇女宫颈癌的关系。方法在内蒙古自治区呼和浩特市蒙古族妇女中,同期选择宫颈癌患者53例,健康对照者65例进行病例——对照研究,采用连接酶检测反应技术分别对入选样本进行基因分型,分析两者之间的相关性。结果在蒙古族妇女中,p53基因第72密码子Arg和Pro等位基因频率在宫颈癌组中分别为51.9%和48.1%,在对照组中分别为50.8%和49.2%,两组等位基因频率分布差异无统计学意义(P>0.05);两组间基因型频率分布差异无统计学意义(P>0.05);p53基因第72密码子多态性和蒙古族妇女宫颈癌无明显相关性。结论 p53基因第72密码子基因多态性和蒙古族妇女宫颈癌无明显相关性,并非是蒙古族妇女宫颈癌的主要因素。Objective To explore the correlation between genetic polymorphism of p53 codon 72 and cervical cancer in Mongolian women.Methods A case-control study was conducted in Mongolian population of Hohhot,Inner Mongolia Autonomous Region,involving 53 women with cervical carcinoma as experimental group,and 65 same ethnic healthy women as control group.Genotyping was performed using the PCR/ligase detection reaction assay.Results Frequency of p53 gene codon 72 Arg and Pro alleles in cervical cancer group were 51.9% and 48.1% while in the control group were 50.8% and 49.2%,there was no significant difference between cervical cancer group and the control group in allele and genotype distribution frequency（P0.05）;There was no significant correlation between codon 72 of p53 gene and cervical cancer in Mongolian women.Conclusion Polymorphism at codon 72 of p53 gene may be not correlated with cervical cancer,codon 72 of p53 gene was not a major factor of cervical cancer in Mongolian women.

关 键 词：P53基因 基因多态性 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]