牛血清白蛋白在医用聚氨酯弹性体表面的吸附  

Adsorption of Bovine Serum Albumin on the Surface of Medical Polyurethane Elastomer

作　　者：尹红根[1] 侯逢文[1] 李艺[1] 程镕时[2] 

机构地区：[1]苏州大学材料与化学化工学部,苏州215123 [2]南京大学化学化工学院,南京210093

出　　处：《高等学校化学学报》2011年第11期2691-2695,共5页Chemical Journal of Chinese Universities

基　　金：江苏省高校自然科学基础研究计划(批准号:08KJB430014);国家自然科学基金(批准号:21074086)资助

摘　　要：制备了具有较好机械性能的异佛尔酮二异氰酸酯(IPDI)型聚氨酯弹性体胶片,并进行表面肝素化处理,得到抗凝血医用导管材料.将聚氨酯胶片浸泡在牛血清白蛋白(BSA)水溶液中,利用稀溶液黏度法研究了牛血清白蛋白在聚氨酯胶片表面的动态吸附情况,并采用界面校正黏度方程计算溶液浓度变化.研究发现,牛血清白蛋白分子能迅速吸附到聚氨酯胶片表面,但达到吸附平衡需要较长时间.牛血清白蛋白在聚氨酯表面吸附后的溶液中分子构象发生变化.A special isophorone diisocyanate （IPDI） type polyurethane （PU） elastomer with good mechanical property was prepared. Heparin was grafted obtained. The dynamic adsorption of bovine on the surface of this PU elastomer and a PU-Hep elastomer was serum albumin （BSA） on PU elastomers was investigated by immersing the PU and PU-Hep elastomers in dilute BSA aqueous solution and measuring the viscosity change of the solution. The results show that BSA macromolecules quickly accumulate on the surface of PU and PU-Hep elastomers, however, it needs a long time to reach the adsorption equilibrium. The conformational chang of BSA macromolecules happens in bulk solution after adsorption on the PU and PU-Hep elastomers.

关 键 词：聚氨酯弹性体 牛血清白蛋白 吸附 黏度 

分 类 号：O631[理学—高分子化学]