奈达铂配合放疗治疗中晚期鼻咽癌的疗效观察  

Curative effect of nedaplatin combined with radiation therapy on advanced nasopharyngeal carcinoma

作　　者：孔飞[1] 蔡白振[1] 

机构地区：[1]海南省人民医院放疗科,海南海口570311

出　　处：《中国热带医学》2011年第9期1139-1140,共2页China Tropical Medicine

摘　　要：目的观察奈达铂联合放疗治疗中晚期鼻咽癌的临床疗效,探讨奈达铂联合放疗治疗中晚期鼻咽癌的可行性。方法将收治的59例患者按随机分组分为观察组与对照组,两组患者均进行放射治疗,在此基础上,观察组予以奈达铂进行化疗,对照组予以顺铂进行化疗,比较两组患者临床疗效及不良反应发生率。结果两组患者均按治疗计划完成放射治疗,对照组1例患者因出现严重过敏反应放弃化疗,观察组患者均按治疗方案完成化疗。观察组与对照组患者临床有效率分别为96.67%与96.43%,两者差异无统计学意义(P>0.05)。观察组患者胃肠道反应的发生率低于对照组,差异具有统计学意义(P<0.05);血小板减低发生率高于对照组(P<0.05);白细胞减低、血红蛋白减低发生率、皮肤黏膜反应发生率与对照组比较差异无统计学意义(P>0.05)。结论奈达铂配合放疗治疗中晚期鼻咽癌近期效果满意,不良反应发生率低于对照组,可在中晚期鼻咽癌的临床治疗中进行推广。Objective To observe the clinical effect of nedaplatin combined with radiation therapy on advanced nasopharyngeal carcinoma.Methods There 59 patients were divided into observation group and control group.The two groups were both treated with radiation therapy,and the observation group were given nedaplatin while the control group were cisplatin.The therapeutic effect and incidence of adverse reactions between the two groups were comared after treatment.Results One case in the control group abandoned the treatment because of severe allergic reaction.The clinical effective rate of the observation group and the control group were 96.67% and 96.43%,without significant difference（P0.05）.The incidence rate of the gastrointestinal reaction was lower in the observation group than the control group（P0.05）.The incidence rate of the thrombocytopenia in the observation group was higher the control group（P0.05）.The incidence rate of the leucopenia and hemoglobin reduction and mucosal injury in the observation group showed no significant difference compared to the control group（P0.05）.Conclusion The therapeutic effect of nedaplatin combined with radiation therapy on advanced nasopharyngeal carcinoma is satisfactory with low side effects.

关 键 词：奈达铂 放射治疗 中晚期鼻咽癌 顺铂 

分 类 号：R739.63[医药卫生—肿瘤]