630例药品不良反应调查分析  

Clinical analysis of adverse drug reactions occurred to 630 cases from 2008 to 2010

作　　者：刘日升[1] 张雯[1] 

机构地区：[1]海南医学院附属医院,海南海口570102

出　　处：《中国热带医学》2011年第9期1154-1155,1160,共3页China Tropical Medicine

摘　　要：目的了解医院药品不良反应（ADR）发生的情况及特点,为临床合理用药及药物安全性评价提供参考。方法对2008~2010年收集的630例不良反应报告表,分别从患者年龄、给药途径、药品种类、抗微生物药物类别、累及的器官或系统及临床表现等方面进行统计分析。结果 ADR多发生在大于60岁年龄组（23.81%）;静脉滴注导致的ADR发生率最高,占71.59%;ADR发生率最高的为抗微生物药物,为62.54%,其中头孢菌素类药物最多,占118例;ADR的临床表现以皮肤及其附件损害最为常见,占44.76%。结论引起ADR的因素有多方面,应加强ADR监测,促进临床合理用药,减少ADR的发生。Objective To analyze the clinical features of adverse drug reactions（ADR） occurred to 630 cases and provide reference for rational use of drugs in the clinical treatment.Methods The route of administration,drug category,anti-microbial drug classification,ADR-involved organs or systems and clinical manifestations,etc.of 630 ADR cases collected from 2008 to 2010 were analyzed statistically.Results Patients over the age of 60 years showed the highest incidence（23.81%）.Most of ADR cases were induced by intravenous administration（71.59%）.62.54% of ADR cases were due to use of anti-microbial drugs,including 118 ADR cases after use of cephalosporins.Main clinical manifestations of ADR cases were lesion of skin and its appendants（44.76%）.Conclusion There are many factors related to occurrence of ADR,thus the monitoring of ADR should be strengthened to ensure rational use of drugs for clinical purposes and reduce the incidence of ADR.

关 键 词：药品不良反应 报告 分析 合理用药 

分 类 号：R155.5[医药卫生—营养与食品卫生学]