固相萃取-液相色谱法同时检测4种酸性PPCPs  

Simultaneous determination of four acidic pharmaceuticals and personal care products by solid phase extraction-high performance liquid chromatography

作　　者：陈方荣[1] 吴波[1] 马培丽[1] 周锦芳[1] 马超[1] 齐玥[1] 陈怀侠[1] 

机构地区：[1]湖北大学化学化工学院,湖北武汉430062

出　　处：《湖北大学学报（自然科学版）》2011年第2期168-173,共6页Journal of Hubei University：Natural Science

基　　金：国家自然科学基金(20975030)资助

摘　　要：建立了固相萃取-液相色谱法同时分析环境水样中水杨酸、酮洛芬、萘普生和双氯芬酸钠等4种酸性PPCPs的方法.水样用0.22μm水系膜过滤两次,C18固相萃取小柱分离富集,甲醇洗脱液直接进行液相色谱分析.实验结果显示,工作曲线范围分别为水杨酸5~200μg/L;酮洛芬2~200μg/L;萘普生0.5~50μg/L和双氯芬酸钠5~200μg/L.检测限（LOD）分别为水杨酸0.15μg/L;酮洛芬0.18μg/L;萘普生0.03μg/L和双氯芬酸钠0.6μg/L.加标回收率在80.2%~104.3%范围内.该方法操作简单？快速？低成本？提取回收率和富集倍数高,适合于环境水样中PPCPs残留的检测.A solid phase extraction followed by high performance liquid chromatography method had been established for the determination of four acidic pharmaceuticals and personal care products.Water samples were filtered through 0.22 μm glass-fiber filters twice,and concentrated through C18 solid phase extraction column.The solutions were analyzed by HPLC directly.The linearity ranges were 5-200 μg/L for Salicylic acid,2-200 μg/L for Ketoprofen,0.5-50 μg/L for Naproxen and 5-200 μg/L for Diclofenac sodium,respectively.The limits of detection（LODs） were 0.15 μg/L for Salicylic acid,0.18 μg/L for Ketoprofen,0.03 μg/L for Naproxen and 0.6 μg/L for Diclofenac sodium,respectively.The recoveries of the pharmceuticals ranged from 80.2% to 104.3%.The method is simple,fast,low-cost,high recovery rate,enrichment factor and is suitable to the detection of PPCPs residues in enviromental water samples.

关 键 词：固相萃取 水样 液相色谱 水杨酸 酮洛芬 萘普生 双氯芬酸钠 

分 类 号：O657[理学—分析化学]