黄腐酸及黄腐酸钠对糖尿病小鼠的降糖作用研究  

Hypoglycemic Effect of Fulvic Acid and Sodium Fulvate on Diabetic Mice

作　　者：何静[1] 毕艳艳[1] 李宝才[1] 李月梅[1] 崔佳丽[1] 梅展青 

机构地区：[1]昆明理工大学生命科学与技术学院,云南昆明650224 [2]香港满好集团云南满好肥料有限公司,云南昆明650106

出　　处：《昆明理工大学学报（自然科学版）》2011年第5期64-69,共6页Journal of Kunming University of Science and Technology(Natural Science)

基　　金：云南省教育厅科学研究基金项目(项目编号:09Y0086);企业联合开发项目(项目编号:KKK0200826106);昆明理工大学分析测试基金项目(项目编号:2010127)

摘　　要：研究黄腐酸及黄腐酸钠的降血糖作用,并对其降糖机制进行初步探讨.采用腹腔注射四氧嘧啶诱导糖尿病小鼠造模,考察黄腐酸及黄腐酸钠对正常小鼠血糖,对糖尿病小鼠血糖、总胆固醇(TC)、血清甘油三酯(TG)以及口服糖耐量的影响.研究表明,中、高剂量黄腐酸及黄腐酸钠能明显降低正常小鼠的血糖含量(P<0.01);中、高剂量黄腐酸及黄腐酸钠明显降低糖尿病小鼠体内血糖、TC、TG的含量(P<0.05或P<0.01),低剂量黄腐酸钠、"旱地龙"、"双龙"黄腐酸则有不同程度的影响;对于口服糖耐量试验,中、高剂量黄腐酸及黄腐酸钠能明显快速降低糖尿病小鼠血糖(P<0.05).结论:黄腐酸及黄腐酸钠明显降低小鼠体内血糖、TC、TG的含量,增加小鼠的口服糖耐量,提示黄腐酸及黄腐酸钠具有降血糖及改善脂质代谢作用.The hypoglycemic effect of fulvic acid and sodium fulvate is studied, and its hypoglycemic mechanism is also preliminarily discussed. The diabetic mice model is induced by the intraperitoneal injection of alloxan. The influences of fulvic acid and sodium fulvate on blood glucose level of normal mice, blood glucose level, total cholesterol（TC） , triglyceride （TG） and oral glucose tolerance of diabetic mice are then studied. It is shown through the results that the middle and high doses of fulvic acid and sodium fulvate can significantly reduce the blood glucose of normal mice （P 〈0.01 ） ; the middle and high doses of fulvic acid and sodium fulvate can sig- nificantly reduce the blood glucose, TC and TG levels of diabetic mice （ P 〈 0.05 or P 〈 0.01 ）. The low doses of sodium fulvate, ＂Handilong＂ and ＂Shuanglong＂ sodium fulvate have the different effects. The middle and high doses of fulvic acid and sodium fulvate ean significantly reduce the blood glucose of diabetic mice in the oral glucose tolerance test （P 〈 0.05 ）. It is concluded that fulvic acid and sodium fulvate can significantly reduce the blood glucose, TC and TG levels of mice, and increase oral glucose tolerance of mice. This indicates that fulvic acid and sodium fulvate has hypoglycemic activity and can improve the lipid metabolism of diabetes.

关 键 词：黄腐酸 黄腐酸钠 降血糖作用 

分 类 号：R285.5[医药卫生—中药学]