广州地区不良孕产史夫妇外周血异常核型分析  

Analysis of chromosome abnormality in 261 couples with aderverse pregnancy outcome history in Guangzhou

作　　者：夏冰[1] 叶长烂[1] 张中芬[1] 郑霖[1] 江悦华[1] 王捷[1] 

机构地区：[1]广州军区广州总医院,广东广州510010

出　　处：《中国优生与遗传杂志》2011年第11期34-35,33,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的观察不良孕产夫妇异常染色体分布类型及其与不良孕产的关系。方法对261对不良孕产夫妇外周血淋巴细胞进行细胞遗传学分析,采用G显带方法。结果 261对不良孕产史夫妇染色体异常80例(15.3%),其中相互易位9例;Turner嵌合体1例;染色体异态70例,包括9号染色体小臂间倒位10例,次缢痕长度增加16例,D组、G组短臂的随体长度增加或减少或双随体共36例,大Y、小Y共8例。结论不良孕产夫妇染色体异常主要为平衡易位和多种染色体异态,后者在不良孕产史夫妇中的高发生率提示其具有一定临床效应。Objective ： To explore the types of chromosome abnormality in the couples with aderverse pregnancy outcome history. Method ： Cytogenetic analysis with G - staining method was performed on the peripheral blood lymphocyte cultures of 261 couples with abnormal pregnancy - labor history. Results ： Chromosome abnormalities were found in 80 patients, including 9 of reciprocal translocation, 1 mosaic Turner syndrome, 70 of chromosome beteromorphism which included 10 of small pericentric inversion of chromosome 9, 16 of increase in length of heterochromatin on long arm of chromosomes, 36 of increase/decrease in satellite length or double satellites on short arms of chromosomes in D and G groups, and 8 of increase/decrease in length of Y chromosome. Conclusion： The chromo- some abnormalities of the couples with adverse pregnancy outcome history are mainly balanced reciprocal translocations and chromosome heteromorphism, and the high incidence of the latter in such couples suggests that it has some clinical effects.

关 键 词：染色体畸变 染色体异态 不良孕产 

分 类 号：R714.2[医药卫生—妇产科学]