新疆维吾尔自治区乌鲁木齐地区466例非霍奇金淋巴瘤临床病理特征分析  

Clinicopathologic characteristics of 466 cases of non-Hodgkin lymphoma in Urumqi area of Xinjiang Uygur Autonomous Region

作　　者：哈德提·别克米托夫[1] 张莉[2] 顾霞[1] 马瑞[1] 陈海霞[1] 王欣[1] 

机构地区：[1]新疆医科大学第一附属医院病理科,乌鲁木齐830054 [2]新疆医科大学第一附属医院肿瘤中心,乌鲁木齐830054

出　　处：《白血病．淋巴瘤》2011年第10期612-615,共4页Journal of Leukemia & Lymphoma

基　　金：国家自然科学基金（30860096）

摘　　要：目的探讨新疆维吾尔自治区乌鲁木齐地区不同民族非霍奇金淋巴瘤（NHL）的临床病理特点。方法收集466例NHL标本，复查HE和免疫组织化学染色结果，重新诊断、分型。结果466例中B细胞性NHL369例（79．2％），T细胞性NHL97例（20.8％）；结内193例（41．4％），结外273例（58．6％）；最常见组织学类型为弥漫大B细胞淋巴瘤、小淋巴细胞淋巴瘤／慢性淋巴细胞白血病、黏膜相关淋巴组织结外边缘区B细胞淋巴瘤、NK／T细胞淋巴瘤、外周T细胞淋巴瘤、滤泡性淋巴瘤。维吾尔族T淋巴母细胞淋巴瘤（T—LBL）和间变性大细胞淋巴瘤（ALCL）比例分别为7．5％（9／120）和4．2％（5／120），高于汉族的1．3％（4／308）和2．3％（7／308）（x2=11．276，P=0．001；x2=1．137，P=0．286）。而汉族结外NK／T细胞淋巴瘤比例为7．1％（22／308），高于维吾尔族的3．3％（4／120），差异无统计学意义（x2=2．196，P=0．138）。其余各亚型在不同民族间差异皆无统计学意义（均P〉0．05）。结论乌鲁木齐地区NHL结外发病高于结内，B细胞性淋巴瘤的发病明显高于我国内地。维吾尔族和汉族B—NHL发病构成在整体上差别不大，但是在T细胞NHL中，维吾尔族T—LBL和ALCL高于汉族，而汉族结外NK／T细胞淋巴瘤高于维吾尔族，这些差异是否与新疆维吾尔自治区的民族与地域差异有关，还需要进一步的研究证实。Objective To investigate the clinicopathologie characteristics of different nation non- Hodgkin lymphoma （NHL） in Urumqi of Xinjiang Uygur Autonomous Region. Methods Four hundred and sixty-six cases of NHL were collected. Their sections including HE and immunobistochemieal staining were examined again for diagnosis and classification. Results Among 466 cases NHL, B cell neoplasm was 369 cases （79,2 %） and T （：ell lymphoma was 97 cases （20.8 %）. 193 cases （41.4 %） oceured in the lymph node and 273 cases （58.6 %） extranodal lymphoma. The most common subtypes were diffuse large B-cell lymphoma, small lymphocytic lymphoma/chronic lymphocytic leukaemia, extranodal marginal zone lymphoma of mueosaassociated lymphoid tissue, NK/T cell lymphoma, peripheral T-cell lymphoma, follicular lymphoma. T- lymphoblastic lymphoma （T-LBL） and anaplastic large cell lymphoma （ALCL） in the Uygur were higher than the Han [7.5 % （9/120） vs 1.3 % （4/308）, X2 = 11.276, P= 0.001; 4.2 % （5/120） vs 2.3 % （7/308）, X2 = 1.137, P = 0.286], and T/NK cell lymphoma in the Han was higher than the Uygur [7.1 （22/308） vs 3.3 % （4/120）, ）（2 = 2.196, P = 0.138]. There was no statistically significance between the Uygur and Han in different subtypes of B-NHL （P 〉0.05）, Conclusion In Urumqi aera, the incidence is higher in extranodal lymphoma than that in nodal. B-NHL is more in Urumqi area than that in other area in our country. There is no difference obviously for mobility B-NHL in the Uygur and Ham but T-LBL and ALCL in the Uygur are higher than those in the Han, and T/NK cell lymphoma in the Han is higher than that in the Uygur. It is suggested to confirm further whether the different associated with different nation and region.

关 键 词：新疆【维吾尔自治区】 维吾尔族 非霍奇金 淋巴瘤 

分 类 号：R733.1[医药卫生—肿瘤]