EB病毒阳性老年人弥漫大B细胞淋巴瘤研究进展  

Research progress of Epstein-Barr virus-positive diffuse large B-cell iymphoma

作　　者：方建晨（综述）[1] 周珏（审校）[1] 

机构地区：[1]浙江省宁波市临床病理诊断中心宁波市医疗中心李惠利医院,315000

出　　处：《白血病．淋巴瘤》2011年第10期631-634,共4页Journal of Leukemia & Lymphoma

摘　　要：在2008版的WHO分类中EB病毒（EBV）阳性老年人弥漫大B细胞淋巴瘤（DLBCL）作为新的类型被单独特别列出。就其发病机制、病理学特征及鉴别诊断、发现DLBCL中的EBV的方法进行讨论，另外还就DLBCL患者中EBV感染状态潜在的预测和预后价值及对这类肿瘤的治疗策略进行讨论。Epstein-Barr virus-positive （EBV-positive） diffuse large B-cell lymphoma （DLBCL） of the elderly is a newly described lymphoproliferative disorder recently in the most current WHO classification of tumours of haematopoietic and lymphoid tissues. The objective of this review is to provide a thorough and current summary of the existing knowledge of this subtype of DLBCL. It will review and discuss the pathogenesis behind EBV-driven malignant transformation of B cells, the distinct pathologic characteristics of EBV-positive DLBCL, the potential predictive and prognostic value of EBV tumoral status in patients with DLBCL, and potential strategies for the treatment of this rare entity.

关 键 词：疱疹病毒4型 人 淋巴瘤 B细胞 老年人 

分 类 号：R733[医药卫生—肿瘤]